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Thirty-day outcomes of children and adolescents with COVID-19:An international experience
- Source :
- Duarte-Salles , T , Vizcaya , D , Pistillo , A , Casajust , P , Sena , A G , Hui Lai , L Y , Prats-Uribe , A , Ahmed , W U R , Alshammari , T M , Alghoul , H , Alser , O , Burn , E , You , S C , Areia , C , Blacketer , C , DuVall , S , Falconer , T , Fernandez-Bertolin , S , Fortin , S , Golozar , A , Gong , M , Tan , E H , Huser , V , Iveli , P , Morales , D R , Nyberg , F , Posada , J D , Recalde , M , Roel , E , Schilling , L M , Shah , N H , Shah , K , Suchard , M A , Zhang , L , Zhang , Y , Williams , A E , Reich , C G , Hripcsak , G , Rijnbeek , P , Ryan , P , Kostka , K & Prieto-Alhambra , D 2021 , ' Thirty-day outcomes of children and adolescents with COVID-19 : An international experience ' , Pediatrics , vol. 148 , no. 3 , e2020042929 .
- Publication Year :
- 2021
-
Abstract
- OBJECTIVES: To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children and adolescents diagnosed or hospitalized with coronavirus disease 2019 (COVID-19) and to compare them in secondary analyses with patients diagnosed with previous seasonal influenza in 2017–2018. METHODS: International network cohort using real-world data from European primary care records (France, Germany, and Spain), South Korean claims and US claims, and hospital databases. We included children and adolescents diagnosed and/or hospitalized with COVID-19 at age <18 between January and June 2020. We described baseline demographics, comorbidities, symptoms, 30-day in-hospital treatments, and outcomes including hospitalization, pneumonia, acute respiratory distress syndrome, multisystem inflammatory syndrome in children, and death. RESULTS: A total of 242 158 children and adolescents diagnosed and 9769 hospitalized with COVID-19 and 2 084 180 diagnosed with influenza were studied. Comorbidities including neurodevelopmental disorders, heart disease, and cancer were more common among those hospitalized with versus diagnosed with COVID-19. Dyspnea, bronchiolitis, anosmia, and gastrointestinal symptoms were more common in COVID-19 than influenza. In-hospital prevalent treatments for COVID-19 included repurposed medications (<10%) and adjunctive therapies: systemic corticosteroids (6.8%–7.6%), famotidine (9.0%–28.1%), and antithrombotics such as aspirin (2.0%–21.4%), heparin (2.2%–18.1%), and enoxaparin (2.8%–14.8%). Hospitalization was observed in 0.3% to 1.3% of the cohort diagnosed with COVID-19, with undetectable (n < 5 per database) 30-day fatality. Thirty-day outcomes including pneumonia and hypoxemia were more frequent in COVID-19 than influenza. CONCLUSIONS: Despite negligible fatality, complications including hospitalization, hypoxemia, and pneumonia were more frequent in children and adolescents with COVID-19 than with inf
Details
- Database :
- OAIster
- Journal :
- Duarte-Salles , T , Vizcaya , D , Pistillo , A , Casajust , P , Sena , A G , Hui Lai , L Y , Prats-Uribe , A , Ahmed , W U R , Alshammari , T M , Alghoul , H , Alser , O , Burn , E , You , S C , Areia , C , Blacketer , C , DuVall , S , Falconer , T , Fernandez-Bertolin , S , Fortin , S , Golozar , A , Gong , M , Tan , E H , Huser , V , Iveli , P , Morales , D R , Nyberg , F , Posada , J D , Recalde , M , Roel , E , Schilling , L M , Shah , N H , Shah , K , Suchard , M A , Zhang , L , Zhang , Y , Williams , A E , Reich , C G , Hripcsak , G , Rijnbeek , P , Ryan , P , Kostka , K & Prieto-Alhambra , D 2021 , ' Thirty-day outcomes of children and adolescents with COVID-19 : An international experience ' , Pediatrics , vol. 148 , no. 3 , e2020042929 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1313638350
- Document Type :
- Electronic Resource