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Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Authors :
Gunawan, ST
Kempe, K
Bonnard, T
Cui, J
Alt, K
Law, LS
Wang, X
Westein, E
Such, GK
Peter, K
Hagemeyer, CE
Caruso, F
Gunawan, ST
Kempe, K
Bonnard, T
Cui, J
Alt, K
Law, LS
Wang, X
Westein, E
Such, GK
Peter, K
Hagemeyer, CE
Caruso, F
Publication Year :
2015

Abstract

Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.

Details

Database :
OAIster
Publication Type :
Electronic Resource
Accession number :
edsoai.on1315662701
Document Type :
Electronic Resource