Back to Search Start Over

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Authors :
Akdemir, KC
Le, VT
Chandran, S
Li, Y
Verhaak, RG
Beroukhim, R
Campbell, PJ
Chin, L
Dixon, JR
Futreal, PA
Alvarez, EG
Baez-Ortega, A
Boutros, PC
Bowtell, DDL
Brors, B
Burns, KH
Chan, K
Chen, K
Cortes-Ciriano, I
Dueso-Barroso, A
Dunford, AJ
Edwards, PA
Estivill, X
Etemadmoghadam, D
Feuerbach, L
Fink, JL
Frenkel-Morgenstern, M
Garsed, DW
Gerstein, M
Gordenin, DA
Haan, D
Haber, JE
Hess, JM
Hutter, B
Imielinski, M
Jones, DTW
Ju, YS
Kazanov, MD
Klimczak, LJ
Koh, Y
Korbel, JO
Kumar, K
Lee, EA
Lee, JJ-K
Lynch, AG
Macintyre, G
Markowetz, F
Martincorena, I
Martinez-Fundichely, A
Meyerson, M
Miyano, S
Nakagawa, H
Navarro, FCP
Ossowski, S
Park, PJ
Pearson, JV
Puiggros, M
Rippe, K
Roberts, ND
Roberts, SA
Rodriguez-Martin, B
Schumacher, SE
Scully, R
Shackleton, M
Sidiropoulos, N
Sieverling, L
Stewart, C
Torrents, D
Tubio, JMC
Villasante, I
Waddell, N
Wala, JA
Weischenfeldt, J
Yang, L
Yao, X
Yoon, S-S
Zamora, J
Zhang, C-Z
Akdemir, KC
Le, VT
Chandran, S
Li, Y
Verhaak, RG
Beroukhim, R
Campbell, PJ
Chin, L
Dixon, JR
Futreal, PA
Alvarez, EG
Baez-Ortega, A
Boutros, PC
Bowtell, DDL
Brors, B
Burns, KH
Chan, K
Chen, K
Cortes-Ciriano, I
Dueso-Barroso, A
Dunford, AJ
Edwards, PA
Estivill, X
Etemadmoghadam, D
Feuerbach, L
Fink, JL
Frenkel-Morgenstern, M
Garsed, DW
Gerstein, M
Gordenin, DA
Haan, D
Haber, JE
Hess, JM
Hutter, B
Imielinski, M
Jones, DTW
Ju, YS
Kazanov, MD
Klimczak, LJ
Koh, Y
Korbel, JO
Kumar, K
Lee, EA
Lee, JJ-K
Lynch, AG
Macintyre, G
Markowetz, F
Martincorena, I
Martinez-Fundichely, A
Meyerson, M
Miyano, S
Nakagawa, H
Navarro, FCP
Ossowski, S
Park, PJ
Pearson, JV
Puiggros, M
Rippe, K
Roberts, ND
Roberts, SA
Rodriguez-Martin, B
Schumacher, SE
Scully, R
Shackleton, M
Sidiropoulos, N
Sieverling, L
Stewart, C
Torrents, D
Tubio, JMC
Villasante, I
Waddell, N
Wala, JA
Weischenfeldt, J
Yang, L
Yao, X
Yoon, S-S
Zamora, J
Zhang, C-Z
Publication Year :
2020

Abstract

Chromatin is folded into successive layers to organize linear DNA. Genes within the same topologically associating domains (TADs) demonstrate similar expression and histone-modification profiles, and boundaries separating different domains have important roles in reinforcing the stability of these features. Indeed, domain disruptions in human cancers can lead to misregulation of gene expression. However, the frequency of domain disruptions in human cancers remains unclear. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we analyzed 288,457 somatic structural variations (SVs) to understand the distributions and effects of SVs across TADs. Notably, SVs can lead to the fusion of discrete TADs, and complex rearrangements markedly change chromatin folding maps in the cancer genomes. Notably, only 14% of the boundary deletions resulted in a change in expression in nearby genes of more than twofold.

Details

Database :
OAIster
Publication Type :
Electronic Resource
Accession number :
edsoai.on1315692364
Document Type :
Electronic Resource