Skip to search
Skip to main content
Back to Search
Start Over
Global Retinoblastoma Presentation and Analysis by National Income Level
Authors :
Fabian, ID Abdallah, E Abdullahi, SU Abdulqader, RA Boubacar, SA Ademola-Popoola, DS Adio, A Afshar, AR Aggarwal, P Aghaji, AE Ahmad, A Akib, MNR Al Harby, L Al Ani, MH Alakbarova, A Portabella, SA Al-Badri, SAF Alcasabas, APA Al-Dahmash, SA Alejos, A Alemany-Rubio, E Bio, AIA Carreras, YA Al-Haddad, C Al-Hussaini, HHY Ali, AM Alia, DB Al-Jadiry, MF Al-Jumaly, U Alkatan, HM All-Eriksson, C Al-Mafrachi, AARM Almeida, AA Alsawidi, KM Al-Shaheen, AASM Al-Shammary, EH Amiruddin, PO Antonino, R Astbury, NJ Atalay, HT Atchaneeyasakul, L-O Atsiaya, R Attaseth, T Aung, TH Ayala, S Baizakova, B Balaguer, J Balayeva, R Balwierz, W Barranco, H Bascaran, C Popovic, MB Benavides, R Benmiloud, S Guebessi, NB Berete, RC Berry, JL Bhaduri, A Bhat, S Biddulph, SJ Biewald, EM Bobrova, N Boehme, M Boldt, HC Bonanomi, MTBC Bornfeld, N Bouda, GC Bouguila, H Boumedane, A Brennan, RC Brichard, BG Buaboonnam, J Calderon-Sotelo, P Calle Jara, DA Camuglia, JE Cano, MR Capra, M Cassoux, N Castela, G Castillo, L Catala-Mora, J Chantada, GL Chaudhry, S Chaugule, SS Chauhan, A Chawla, B Chernodrinska, VS Chiwanga, FS Chuluunbat, T Cieslik, K Cockcroft, RL Comsa, C Correa, ZM Correa Llano, MG Corson, TW Cowan-Lyn, KE Csoka, M Cui, X Da Gama, I Dangboon, W Das, A Das, S Davanzo, JM Davidson, A De Potter, P Delgado, KQ Demirci, H Desjardins, L Diaz Coronado, RY Dimaras, H Dodgshun, AJ Donaldson, C Donato Macedo, CR Dragomir, MD Du, Y Du Bruyn, M Edison, KS Sutyawan, IWE El Kettani, A Elbahi, AM Elder, JE Elgalaly, D Elhaddad, AM Elhassan, MMA Elzembely, MM Essuman, VA Evina, TGA Fadoo, Z Fandino, AC Faranoush, M Fasina, O Fernandez, DDPG Fernandez-Teijeiro, A Foster, A Frenkel, S Fu, LD Fuentes-Alabi, SL Gallie, BL Gandiwa, M Garcia, JL Garcia Aldana, D Gassant, PY Geel, JA Ghassemi, F Giron, A Gizachew, Z Goenz, MA Gold, AS Goldberg-Lavid, M Gole, GA Gomel, N Gonzalez, E Gonzalez Perez, G Gonzalez-Rodriguez, L Garcia Pacheco, HN Graells, J Green, L Gregersen, PA Grigorovski, NDAK Guedenon, KM Gunasekera, DS Gunduz, AK Gupta, H Gupta, S Hadjistilianou, T Hamel, P Hamid, SA Hamzah, N Hansen, ED Harbour, JW Hartnett, ME Hasanreisoglu, M Hassan, S Hederova, S Hernandez, J Carcamo Hernandez, LM Hessissen, L Hordofa, DF Huang, LC Hubbard, GB Hummlen, M Husakova, K Al-Janabi, ANH Ida, R Ilic, VR Jairaj, V Jeeva, I Jenkinson, H Ji, X Jo, DH Johnson, KP Johnson, WJ Jones, MM Kabesha, TBA Kabore, RL Kaliki, S Kalinaki, A Kantar, M Kao, L-Y Kardava, T Kebudi, R Kepak, T Keren-Froim, N Khan, ZJ Khaqan, HA Khauv, P Kheir, WJ Khetan, V Khodabande, A Khotenashvili, Z Kim, JW Kim, JH Kiratli, H Kivela, TT Klett, A Palet, JEKK Krivaitiene, D Kruger, M Kulvichit, K Kuntorini, MW Kyara, A Lachmann, ES Lam, CPS Lam, GC Larson, SA Latinovic, S Laurenti, KD Le, BHA Lecuona, K Leverant, AA Li, C Limbu, B Quah, BL Lopez, JP Lukamba, RM Lumbroso, L Luna-Fineman, S Lutfi, D Lysytsia, L Magrath, GN Mahajan, A Majeed, AR Maka, E Makan, M Makimbetov, EK Manda, C Martin Begue, N Mason, L Mason, JO Matende, IO Materin, M Mattosinho, CCDS Matua, M Mayet, I Mbumba, FB McKenzie, JD Medina-Sanson, A Mehrvar, A Mengesha, AA Menon, V Mercado, GJVD Mets, MB Midena, E Mishra, DKC Mndeme, FG Mohamedani, AA Mohammad, MT Moll, AC Montero, MM Morales, RA Moreira, C Mruthyunjaya, P Msina, MS Msukwa, G Mudaliar, SS Muma, K Munier, FL Murgoi, G Murray, TG Musa, KO Mushtaq, A Mustak, H Muyen, OM Naidu, G Nair, AG Naumenko, L Roth, PAN Nency, YM Neroev, V Ngo, H Nieves, RM Nikitovic, M Nkanga, ED Nkumbe, H Nuruddin, M Nyaywa, M Obono-Obiang, G Oguego, NC Olechowski, A Oliver, SCN Osei-Bonsu, P Ossandon, D Paez-Escamilla, MA Pagarra, H Painter, SL Paintsil, V Paiva, L Pal, BP Palanivelu, MS Papyan, R Parrozzani, R Parulekar, M Morales, CRP Paton, KE Pawinska-Wasikowska, K Pe'er, J Pena, A Peric, S Pham, CTM Philbert, R Plager, DA Pochop, P Polania, RA Polyakov, VG Pompe, MT Pons, JJ Prat, D Prom, V Purwanto, I Qadir, AO Qayyum, S Qian, J Rahman, A Rahman, S Rahmat, J Rajkarnikar, P Ramanjulu, R Ramasubramanian, A Ramirez-Ortiz, MA Raobela, L Rashid, R Reddy, MA Reich, E Renner, LA Reynders, D Ribadu, D Riheia, MM Ritter-Sovinz, P Rojanaporn, D Romero, L Roy, SR Saab, RH Saakyan, S Sabhan, AH Sagoo, MS Said, AMA Saiju, R Salas, B San Roman Pacheco, S Sanchez, GL Sayalith, P Scanlan, TA Schefler, AC Schoeman, J Sedaghat, A Seregard, S Seth, R Shah, AS Shakoor, SA Sharma, MK Sherief, ST Shetye, NG Shields, CL Siddiqui, SN Cheikh, SS Silva, S Singh, AD Singh, N Singh, U Singha, P Sitorus, RS Skalet, AH Soebagjo, HD Sorochynska, T Ssali, G Stacey, AW Staffieri, SE Stahl, ED Stathopoulos, C Kranjc, BS Stones, DK Strahlendorf, C Suarez, MEC Sultana, S Sun, X Sundy, M Superstein, R Supriyadi, E Surukrattanaskul, S Suzuki, S Svojgr, K Sylla, F Tamamyan, G Tan, D Tandili, A Tarrillo Leiva, FF Tashvighi, M Tateshi, B Tehuteru, ES Teixeira, LF Teh, KH Theophile, T Toledano, H Trang, DL Traore, F Trichaiyaporn, S Tuncer, S Tyau-Tyau, H Umar, AB Unal, E Uner, OE Urbak, SF Ushakova, TL Usmanov, RH Valeina, S Wijsard, MVH Varadisai, A Vasquez, L Vaughan, LO Veleva-Krasteva, NV Verma, N Victor, AA Viksnins, M Villacos Chafla, EG Vishnevskia-Dai, V Vora, T Wachtel, AE Wackernagel, W Waddell, K Wade, PD Wali, AH Wang, Y-Z Weiss, A Wilson, MW Wime, ADC Wiwatwongwana, A Wiwatwongwana, D Dod, CW Wongwai, P Xiang, D Xiao, Y Yam, JC Yang, H Yanga, JM Yaqub, MA Yarovaya, VA Yarovoy, AA Ye, H Yousef, YA Yuliawati, P Zapata Lopez, AM Zein, E Zhang, C Zhang, Y Zhao, J Zheng, X Zhilyaeva, K Zia, N Ziko, OAO Zondervan, M Bowman, R Fabian, ID Abdallah, E Abdullahi, SU Abdulqader, RA Boubacar, SA Ademola-Popoola, DS Adio, A Afshar, AR Aggarwal, P Aghaji, AE Ahmad, A Akib, MNR Al Harby, L Al Ani, MH Alakbarova, A Portabella, SA Al-Badri, SAF Alcasabas, APA Al-Dahmash, SA Alejos, A Alemany-Rubio, E Bio, AIA Carreras, YA Al-Haddad, C Al-Hussaini, HHY Ali, AM Alia, DB Al-Jadiry, MF Al-Jumaly, U Alkatan, HM All-Eriksson, C Al-Mafrachi, AARM Almeida, AA Alsawidi, KM Al-Shaheen, AASM Al-Shammary, EH Amiruddin, PO Antonino, R Astbury, NJ Atalay, HT Atchaneeyasakul, L-O Atsiaya, R Attaseth, T Aung, TH Ayala, S Baizakova, B Balaguer, J Balayeva, R Balwierz, W Barranco, H Bascaran, C Popovic, MB Benavides, R Benmiloud, S Guebessi, NB Berete, RC Berry, JL Bhaduri, A Bhat, S Biddulph, SJ Biewald, EM Bobrova, N Boehme, M Boldt, HC Bonanomi, MTBC Bornfeld, N Bouda, GC Bouguila, H Boumedane, A Brennan, RC Brichard, BG Buaboonnam, J Calderon-Sotelo, P Calle Jara, DA Camuglia, JE Cano, MR Capra, M Cassoux, N Castela, G Castillo, L Catala-Mora, J Chantada, GL Chaudhry, S Chaugule, SS Chauhan, A Chawla, B Chernodrinska, VS Chiwanga, FS Chuluunbat, T Cieslik, K Cockcroft, RL Comsa, C Correa, ZM Correa Llano, MG Corson, TW Cowan-Lyn, KE Csoka, M Cui, X Da Gama, I Dangboon, W Das, A Das, S Davanzo, JM Davidson, A De Potter, P Delgado, KQ Demirci, H Desjardins, L Diaz Coronado, RY Dimaras, H Dodgshun, AJ Donaldson, C Donato Macedo, CR Dragomir, MD Du, Y Du Bruyn, M Edison, KS Sutyawan, IWE El Kettani, A Elbahi, AM Elder, JE Elgalaly, D Elhaddad, AM Elhassan, MMA Elzembely, MM Essuman, VA Evina, TGA Fadoo, Z Fandino, AC Faranoush, M Fasina, O Fernandez, DDPG Fernandez-Teijeiro, A Foster, A Frenkel, S Fu, LD Fuentes-Alabi, SL Gallie, BL Gandiwa, M Garcia, JL Garcia Aldana, D Gassant, PY Geel, JA Ghassemi, F Giron, A Gizachew, Z Goenz, MA Gold, AS Goldberg-Lavid, M Gole, GA Gomel, N Gonzalez, E Gonzalez Perez, G Gonzalez-Rodriguez, L Garcia Pacheco, HN Graells, J Green, L Gregersen, PA Grigorovski, NDAK Guedenon, KM Gunasekera, DS Gunduz, AK Gupta, H Gupta, S Hadjistilianou, T Hamel, P Hamid, SA Hamzah, N Hansen, ED Harbour, JW Hartnett, ME Hasanreisoglu, M Hassan, S Hederova, S Hernandez, J Carcamo Hernandez, LM Hessissen, L Hordofa, DF Huang, LC Hubbard, GB Hummlen, M Husakova, K Al-Janabi, ANH Ida, R Ilic, VR Jairaj, V Jeeva, I Jenkinson, H Ji, X Jo, DH Johnson, KP Johnson, WJ Jones, MM Kabesha, TBA Kabore, RL Kaliki, S Kalinaki, A Kantar, M Kao, L-Y Kardava, T Kebudi, R Kepak, T Keren-Froim, N Khan, ZJ Khaqan, HA Khauv, P Kheir, WJ Khetan, V Khodabande, A Khotenashvili, Z Kim, JW Kim, JH Kiratli, H Kivela, TT Klett, A Palet, JEKK Krivaitiene, D Kruger, M Kulvichit, K Kuntorini, MW Kyara, A Lachmann, ES Lam, CPS Lam, GC Larson, SA Latinovic, S Laurenti, KD Le, BHA Lecuona, K Leverant, AA Li, C Limbu, B Quah, BL Lopez, JP Lukamba, RM Lumbroso, L Luna-Fineman, S Lutfi, D Lysytsia, L Magrath, GN Mahajan, A Majeed, AR Maka, E Makan, M Makimbetov, EK Manda, C Martin Begue, N Mason, L Mason, JO Matende, IO Materin, M Mattosinho, CCDS Matua, M Mayet, I Mbumba, FB McKenzie, JD Medina-Sanson, A Mehrvar, A Mengesha, AA Menon, V Mercado, GJVD Mets, MB Midena, E Mishra, DKC Mndeme, FG Mohamedani, AA Mohammad, MT Moll, AC Montero, MM Morales, RA Moreira, C Mruthyunjaya, P Msina, MS Msukwa, G Mudaliar, SS Muma, K Munier, FL Murgoi, G Murray, TG Musa, KO Mushtaq, A Mustak, H Muyen, OM Naidu, G Nair, AG Naumenko, L Roth, PAN Nency, YM Neroev, V Ngo, H Nieves, RM Nikitovic, M Nkanga, ED Nkumbe, H Nuruddin, M Nyaywa, M Obono-Obiang, G Oguego, NC Olechowski, A Oliver, SCN Osei-Bonsu, P Ossandon, D Paez-Escamilla, MA Pagarra, H Painter, SL Paintsil, V Paiva, L Pal, BP Palanivelu, MS Papyan, R Parrozzani, R Parulekar, M Morales, CRP Paton, KE Pawinska-Wasikowska, K Pe'er, J Pena, A Peric, S Pham, CTM Philbert, R Plager, DA Pochop, P Polania, RA Polyakov, VG Pompe, MT Pons, JJ Prat, D Prom, V Purwanto, I Qadir, AO Qayyum, S Qian, J Rahman, A Rahman, S Rahmat, J Rajkarnikar, P Ramanjulu, R Ramasubramanian, A Ramirez-Ortiz, MA Raobela, L Rashid, R Reddy, MA Reich, E Renner, LA Reynders, D Ribadu, D Riheia, MM Ritter-Sovinz, P Rojanaporn, D Romero, L Roy, SR Saab, RH Saakyan, S Sabhan, AH Sagoo, MS Said, AMA Saiju, R Salas, B San Roman Pacheco, S Sanchez, GL Sayalith, P Scanlan, TA Schefler, AC Schoeman, J Sedaghat, A Seregard, S Seth, R Shah, AS Shakoor, SA Sharma, MK Sherief, ST Shetye, NG Shields, CL Siddiqui, SN Cheikh, SS Silva, S Singh, AD Singh, N Singh, U Singha, P Sitorus, RS Skalet, AH Soebagjo, HD Sorochynska, T Ssali, G Stacey, AW Staffieri, SE Stahl, ED Stathopoulos, C Kranjc, BS Stones, DK Strahlendorf, C Suarez, MEC Sultana, S Sun, X Sundy, M Superstein, R Supriyadi, E Surukrattanaskul, S Suzuki, S Svojgr, K Sylla, F Tamamyan, G Tan, D Tandili, A Tarrillo Leiva, FF Tashvighi, M Tateshi, B Tehuteru, ES Teixeira, LF Teh, KH Theophile, T Toledano, H Trang, DL Traore, F Trichaiyaporn, S Tuncer, S Tyau-Tyau, H Umar, AB Unal, E Uner, OE Urbak, SF Ushakova, TL Usmanov, RH Valeina, S Wijsard, MVH Varadisai, A Vasquez, L Vaughan, LO Veleva-Krasteva, NV Verma, N Victor, AA Viksnins, M Villacos Chafla, EG Vishnevskia-Dai, V Vora, T Wachtel, AE Wackernagel, W Waddell, K Wade, PD Wali, AH Wang, Y-Z Weiss, A Wilson, MW Wime, ADC Wiwatwongwana, A Wiwatwongwana, D Dod, CW Wongwai, P Xiang, D Xiao, Y Yam, JC Yang, H Yanga, JM Yaqub, MA Yarovaya, VA Yarovoy, AA Ye, H Yousef, YA Yuliawati, P Zapata Lopez, AM Zein, E Zhang, C Zhang, Y Zhao, J Zheng, X Zhilyaeva, K Zia, N Ziko, OAO Zondervan, M Bowman, R
Publication Year :
2020
Abstract
IMPORTANCE: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. OBJECTIVES: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. DESIGN, SETTING, AND PARTICIPANTS: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. MAIN OUTCOMES AND MEASURES: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. RESULTS: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis
Details
Database :
OAIster
Publication Type :
Electronic Resource
Accession number :
edsoai.on1315697852
Document Type :
Electronic Resource