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Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET

Authors :
Song, M
Beyer, L
Kaiser, L
Barthel, H
van Eimeren, T
Marek, K
Nitschmann, A
Scheifele, M
Palleis, C
Respondek, G
Kern, M
Biechele, G
Hammes, J
Bischof, G
Barbe, M
Onur, O
Jessen, F
Saur, D
Schroeter, ML
Rumpf, J-J
Rullmann, M
Schildan, A
Patt, M
Neumaier, B
Barret, O
Madonia, J
Russell, DS
Stephens, AW
Mueller, A
Roeber, S
Herms, J
Botzel, K
Danek, A
Levin, J
Classen, J
Hoglinger, GU
Bartenstein, P
Villemagne, V
Drzezga, A
Seibyl, J
Sabri, O
Boening, G
Ziegler, S
Brendel, M
Song, M
Beyer, L
Kaiser, L
Barthel, H
van Eimeren, T
Marek, K
Nitschmann, A
Scheifele, M
Palleis, C
Respondek, G
Kern, M
Biechele, G
Hammes, J
Bischof, G
Barbe, M
Onur, O
Jessen, F
Saur, D
Schroeter, ML
Rumpf, J-J
Rullmann, M
Schildan, A
Patt, M
Neumaier, B
Barret, O
Madonia, J
Russell, DS
Stephens, AW
Mueller, A
Roeber, S
Herms, J
Botzel, K
Danek, A
Levin, J
Classen, J
Hoglinger, GU
Bartenstein, P
Villemagne, V
Drzezga, A
Seibyl, J
Sabri, O
Boening, G
Ziegler, S
Brendel, M
Publication Year :
2021

Abstract

The novel tau-PET tracer [18F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer's disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [18F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies.

Details

Database :
OAIster
Publication Type :
Electronic Resource
Accession number :
edsoai.on1315724931
Document Type :
Electronic Resource