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Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth:A Systematic Review and Meta-analysis
- Source :
- Korevaar , T I M , Derakhshan , A , Taylor , P N , Meima , M , Chen , L , Bliddal , S , Carty , D M , Meems , M , Vaidya , B , Shields , B , Ghafoor , F , Popova , P V , Mosso , L , Oken , E , Suvanto , E , Hisada , A , Yoshinaga , J , Brown , S J , Bassols , J , Auvinen , J , Bramer , W M , López-Bermejo , A , Dayan , C , Boucai , L , Vafeiadi , M , Grineva , E N , Tkachuck , A S , Pop , V J M , Vrijkotte , T G , Guxens , M , Chatzi , L , Sunyer , J , Jiménez-Zabala , A , Riaño , I , Murcia , M , Lu , X , Mukhtar , S , Delles , C , Feldt-Rasmussen , U , Nelson , S M , Alexander , E K , Chaker , L , Männistö , T , Walsh , J P , Pearce , E N , Steegers , E A P , Peeters , R P & Consortium on Thyroid and Pregnancy—Study Group on Preterm Birth 2019 , ' Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth : A Systematic Review and Meta-analysis ' , J A M A: The Journal of the American Medical Association , vol. 322 , no. 7 , pp. 632-641 .
- Publication Year :
- 2019
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Abstract
- Importance: Maternal hypothyroidism and hyperthyroidism are risk factors for preterm birth. Milder thyroid function test abnormalities and thyroid autoimmunity are more prevalent, but it remains controversial if these are associated with preterm birth.Objective: To study if maternal thyroid function test abnormalities and thyroid autoimmunity are risk factors for preterm birth.Data Sources and Study Selection: Studies were identified through a search of the Ovid MEDLINE, EMBASE, Web of Science, the Cochrane Central Register of Controlled Trials, and Google Scholar databases from inception to March 18, 2018, and by publishing open invitations in relevant journals. Data sets from published and unpublished prospective cohort studies with data on thyroid function tests (thyrotropin [often referred to as thyroid-stimulating hormone or TSH] and free thyroxine [FT4] concentrations) or thyroid peroxidase (TPO) antibody measurements and gestational age at birth were screened for eligibility by 2 independent reviewers. Studies in which participants received treatment based on abnormal thyroid function tests were excluded.Data Extraction and Synthesis: The primary authors provided individual participant data that were analyzed using mixed-effects models.Main Outcomes and Measures: The primary outcome was preterm birth (<37 weeks' gestational age).Results: From 2526 published reports, 35 cohorts were invited to participate. After the addition of 5 unpublished data sets, a total of 19 cohorts were included. The study population included 47 045 pregnant women (mean age, 29 years; median gestational age at blood sampling, 12.9 weeks), of whom 1234 (3.1%) had subclinical hypothyroidism (increased thyrotropin concentration with normal FT4 concentration), 904 (2.2%) had isolated hypothyroxinemia (decreased FT4 concentration with normal thyrotropin concentration), and 3043 (7.5%) were TPO antibody positive; 2357 (5.0%) had a preterm birth. The
Details
- Database :
- OAIster
- Journal :
- Korevaar , T I M , Derakhshan , A , Taylor , P N , Meima , M , Chen , L , Bliddal , S , Carty , D M , Meems , M , Vaidya , B , Shields , B , Ghafoor , F , Popova , P V , Mosso , L , Oken , E , Suvanto , E , Hisada , A , Yoshinaga , J , Brown , S J , Bassols , J , Auvinen , J , Bramer , W M , López-Bermejo , A , Dayan , C , Boucai , L , Vafeiadi , M , Grineva , E N , Tkachuck , A S , Pop , V J M , Vrijkotte , T G , Guxens , M , Chatzi , L , Sunyer , J , Jiménez-Zabala , A , Riaño , I , Murcia , M , Lu , X , Mukhtar , S , Delles , C , Feldt-Rasmussen , U , Nelson , S M , Alexander , E K , Chaker , L , Männistö , T , Walsh , J P , Pearce , E N , Steegers , E A P , Peeters , R P & Consortium on Thyroid and Pregnancy—Study Group on Preterm Birth 2019 , ' Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth : A Systematic Review and Meta-analysis ' , J A M A: The Journal of the American Medical Association , vol. 322 , no. 7 , pp. 632-641 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1322742908
- Document Type :
- Electronic Resource