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Freeze-all versus fresh blastocyst transfer strategy during in vitro fertilisation in women with regular menstrual cycles:multicentre randomised controlled trial
- Source :
- Stormlund , S , Sopa , N , Zedeler , A , Bogstad , J , Prætorius , L , Nielsen , H S , Kitlinski , M L , Skouby , S O , Mikkelsen , A L , Spangmose , A L , Jeppesen , J V , Khatibi , A , la Cour Freiesleben , N , Ziebe , S , Polyzos , N P , Bergh , C , Humaidan , P , Andersen , A N , Løssl , K & Pinborg , A 2020 , ' Freeze-all versus fresh blastocyst transfer strategy during in vitro fertilisation in women with regular menstrual cycles : multicentre randomised controlled trial ' , The BMJ , vol. 370 , m2519 .
- Publication Year :
- 2020
-
Abstract
- OBJECTIVE: To compare the ongoing pregnancy rate between a freeze-all strategy and a fresh transfer strategy in assisted reproductive technology treatment.DESIGN: Multicentre, randomised controlled superiority trial.SETTING: Outpatient fertility clinics at eight public hospitals in Denmark, Sweden, and Spain.PARTICIPANTS: 460 women aged 18-39 years with regular menstrual cycles starting their first, second, or third treatment cycle of in vitro fertilisation or intracytoplasmic sperm injection.INTERVENTIONS: Women were randomised at baseline on cycle day 2 or 3 to one of two treatment groups: the freeze-all group (elective freezing of all embryos) who received gonadotropin releasing hormone agonist triggering and single frozen-thawed blastocyst transfer in a subsequent modified natural cycle; or the fresh transfer group who received human chorionic gonadotropin triggering and single blastocyst transfer in the fresh cycle. Women in the fresh transfer group with more than 18 follicles larger than 11 mm on the day of triggering had elective freezing of all embryos and postponement of transfer as a safety measure.MAIN OUTCOME MEASURES: The primary outcome was the ongoing pregnancy rate defined as a detectable fetal heart beat after eight weeks of gestation. Secondary outcomes were live birth rate, positive human chorionic gonadotropin rate, time to pregnancy, and pregnancy related, obstetric, and neonatal complications. The primary analysis was performed according to the intention-to-treat principle.RESULTS: Ongoing pregnancy rate did not differ significantly between the freeze-all and fresh transfer groups (27.8% (62/223) v 29.6% (68/230); risk ratio 0.98, 95% confidence interval 0.87 to 1.10, P=0.76). Additionally, no significant difference was found in the live birth rate (27.4% (61/223) for the freeze-all group and 28.7% (66/230) for the fresh transfer group; risk ratio 0.98, 95% confidence interval 0.87 to 1.10, P=0.83).
Details
- Database :
- OAIster
- Journal :
- Stormlund , S , Sopa , N , Zedeler , A , Bogstad , J , Prætorius , L , Nielsen , H S , Kitlinski , M L , Skouby , S O , Mikkelsen , A L , Spangmose , A L , Jeppesen , J V , Khatibi , A , la Cour Freiesleben , N , Ziebe , S , Polyzos , N P , Bergh , C , Humaidan , P , Andersen , A N , Løssl , K & Pinborg , A 2020 , ' Freeze-all versus fresh blastocyst transfer strategy during in vitro fertilisation in women with regular menstrual cycles : multicentre randomised controlled trial ' , The BMJ , vol. 370 , m2519 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1322751129
- Document Type :
- Electronic Resource