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Genetic variants associated with longitudinal changes in brain structure across the lifespan
Authors :
Brouwer, RM Klein, M Grasby, KL Schnack, HG Jahanshad, N Teeuw, J Thomopoulos, SI Sprooten, E Franz, CE Gogtay, N Kremen, WS Panizzon, MS Olde Loohuis, LM Whelan, CD Aghajani, M Alloza, C Alanaes, D Artiges, E Ayesa-Arriola, R Barker, GJ Bastin, ME Blok, E Boen, E Breukelaar, IA Bright, JK Buimer, EEL Bulow, R Cannon, DM Ciufolini, S Crossley, NA Damatac, CG Dazzan, P de Mol, CL de Zwarte, SMC Desrivieres, S Diaz-Caneja, CM Doan, NT Dohm, K Froehner, JH Goltermann, J Grigis, A Grotegerd, D Han, LKM Harris, MA Hartman, CA Heany, SJ Heindel, W Heslenfeld, DJ Hohmann, S Ittermann, B Jansen, PR Janssen, J Jia, T Jiang, J Jockwitz, C Karali, T Keeser, D Koevoets, MGJC Lenroot, RK Malchow, B Mandl, RCW Medel, V Meinert, S Morgan, CA Muehleisen, TW Nabulsi, L Opel, N de la Foz, VO-G Overs, BJ Paillere Martinot, M-L Redlich, R Marques, TR Repple, J Roberts, G Roshchupkin, GV Setiaman, N Shumskaya, E Stein, F Sudre, G Takahashi, S Thalamuthu, A Tordesillas-Gutierrez, D van der Lugt, A van Haren, NEM Wardlaw, JM Wen, W Westeneng, H-J Wittfeld, K Zhu, AH Zugman, A Armstrong, NJ Bonfiglio, G Bralten, J Dalvie, S Davies, G Di Forti, M Ding, L Donohoe, G Forstner, AJ Gonzalez-Penas, J Guimaraes, JPOFT Homuth, G Hottenga, J-J Knol, MJ Kwok, JBJ Le Hellard, S Mather, KA Milaneschi, Y Morris, DW Noethen, MM Papiol, S Rietschel, M Santoro, ML Steen, VM Stein, JL Streit, F Tankard, RM Teumer, A van 't Ent, D van der Meer, D van Eijk, KR Vassos, E Vazquez-Bourgon, J Witt, SH Adams, HHH Agartz, I Ames, D Amunts, K Andreassen, OA Arango, C Banaschewski, T Baune, BT Belangero, SI Bokde, ALW Boomsma, DI Bressan, RA Brodaty, H Buitelaar, JK Cahn, W Caspers, S Cichon, S Crespo-Facorro, B Cox, SR Dannlowski, U Elvsashagen, T Espeseth, T Falkai, PG Fisher, SE Flor, H Fullerton, JM Garavan, H Gowland, PA Grabe, HJ Hahn, T Heinz, A Hillegers, M Hoare, J Hoekstra, PJ Ikram, MA Jackowski, AP Jansen, A Jonsson, EG Kahn, RS Kircher, T Korgaonkar, MS Krug, A Lemaitre, H Malt, UF Martinot, J-L McDonald, C Mitchell, PB Muetzel, RL Murray, RM Nees, F Nenadic, I Oosterlaan, J Ophoff, RA Pan, PM Penninx, BWJH Poustka, L Sachdev, PS Salum, GA Schofield, PR Schumann, G Shaw, P Sim, K Smolka, MN Stein, DJ Trollor, JN van den Berg, LH Veldink, JH Walter, H Westlye, LT Whelan, R White, T Wright, MJ Medland, SE Franke, B Thompson, PM Hulshoff Pol, HE Brouwer, RM Klein, M Grasby, KL Schnack, HG Jahanshad, N Teeuw, J Thomopoulos, SI Sprooten, E Franz, CE Gogtay, N Kremen, WS Panizzon, MS Olde Loohuis, LM Whelan, CD Aghajani, M Alloza, C Alanaes, D Artiges, E Ayesa-Arriola, R Barker, GJ Bastin, ME Blok, E Boen, E Breukelaar, IA Bright, JK Buimer, EEL Bulow, R Cannon, DM Ciufolini, S Crossley, NA Damatac, CG Dazzan, P de Mol, CL de Zwarte, SMC Desrivieres, S Diaz-Caneja, CM Doan, NT Dohm, K Froehner, JH Goltermann, J Grigis, A Grotegerd, D Han, LKM Harris, MA Hartman, CA Heany, SJ Heindel, W Heslenfeld, DJ Hohmann, S Ittermann, B Jansen, PR Janssen, J Jia, T Jiang, J Jockwitz, C Karali, T Keeser, D Koevoets, MGJC Lenroot, RK Malchow, B Mandl, RCW Medel, V Meinert, S Morgan, CA Muehleisen, TW Nabulsi, L Opel, N de la Foz, VO-G Overs, BJ Paillere Martinot, M-L Redlich, R Marques, TR Repple, J Roberts, G Roshchupkin, GV Setiaman, N Shumskaya, E Stein, F Sudre, G Takahashi, S Thalamuthu, A Tordesillas-Gutierrez, D van der Lugt, A van Haren, NEM Wardlaw, JM Wen, W Westeneng, H-J Wittfeld, K Zhu, AH Zugman, A Armstrong, NJ Bonfiglio, G Bralten, J Dalvie, S Davies, G Di Forti, M Ding, L Donohoe, G Forstner, AJ Gonzalez-Penas, J Guimaraes, JPOFT Homuth, G Hottenga, J-J Knol, MJ Kwok, JBJ Le Hellard, S Mather, KA Milaneschi, Y Morris, DW Noethen, MM Papiol, S Rietschel, M Santoro, ML Steen, VM Stein, JL Streit, F Tankard, RM Teumer, A van 't Ent, D van der Meer, D van Eijk, KR Vassos, E Vazquez-Bourgon, J Witt, SH Adams, HHH Agartz, I Ames, D Amunts, K Andreassen, OA Arango, C Banaschewski, T Baune, BT Belangero, SI Bokde, ALW Boomsma, DI Bressan, RA Brodaty, H Buitelaar, JK Cahn, W Caspers, S Cichon, S Crespo-Facorro, B Cox, SR Dannlowski, U Elvsashagen, T Espeseth, T Falkai, PG Fisher, SE Flor, H Fullerton, JM Garavan, H Gowland, PA Grabe, HJ Hahn, T Heinz, A Hillegers, M Hoare, J Hoekstra, PJ Ikram, MA Jackowski, AP Jansen, A Jonsson, EG Kahn, RS Kircher, T Korgaonkar, MS Krug, A Lemaitre, H Malt, UF Martinot, J-L McDonald, C Mitchell, PB Muetzel, RL Murray, RM Nees, F Nenadic, I Oosterlaan, J Ophoff, RA Pan, PM Penninx, BWJH Poustka, L Sachdev, PS Salum, GA Schofield, PR Schumann, G Shaw, P Sim, K Smolka, MN Stein, DJ Trollor, JN van den Berg, LH Veldink, JH Walter, H Westlye, LT Whelan, R White, T Wright, MJ Medland, SE Franke, B Thompson, PM Hulshoff Pol, HE
Publication Year :
2022
Abstract
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.
Details
Database :
OAIster
Publication Type :
Electronic Resource
Accession number :
edsoai.on1340015103
Document Type :
Electronic Resource