High Expression of DEPDC1B Predicts Poor Prognosis in Lung Adenocarcinoma

Pulin Li,1,* Xiaojuan Chen,2,* Sijing Zhou,3,* Xingyuan Xia,1 Enze Wang,1 Rui Han,1 Daxiong Zeng,4,5 Guanghe Fei,1 Ran Wang1 1Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2Department of Infectious Diseases, Hefei Second People’s Hospital, Hefei, People’s Republic of China; 3Department of Occupational Medicine, Hefei Third Clinical College of Anhui Medical University, Hefei, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, Suzhou Dushu Lake Hospital, Suzhou, People’s Republic of China; 5Department of Pulmonary and Critical Care Medicine, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanghe Fei; Ran Wang, Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China, Tel/Fax +86 -551-62922913, Email guanghefei@hotmail.com; wangran@ahmu.edu.cnIntroduction: Lung adenocarcinoma (LUAD) is the most common type of lung cancer. DEP domain-containing 1 B (DEPDC1B) is involved in the development of several cancers; however, its role in LUAD is unknown. Therefore, we aimed to determine the biological function and prognostic value of DEPDC1B in LUAD.Material and Methods: We analyzed the correlation between DEPDC1B expression and the clinical features of LUAD and lung squamous cell carcinoma (LUSC). Survival was evaluated by generating Kaplan–Meier curves, which were used to analyze the relationship between DEPDC1B expression and prognosis in LUAD and LUSC. DEPDC1B expression in tumor and normal tissues from patients with LUAD and LUSC was determined using immunohistochemistry, and its clinical significance was analyzed. Finally, the correlatio