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Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model

Authors :
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
Ragon Institute of MGH, MIT and Harvard
Friedman, Alexander
Hueske, Emily
Drammis, Sabrina M
Toro Arana, Sebastian E
Nelson, Erik D
Carter, Cody W
Delcasso, Sebastien
Rodriguez, Raimundo X
Lutwak, Hope
DiMarco, Kaden S
Zhang, Qingyang
Rakocevic, Lara I
Hu, Dan
Xiong, Joshua K
Zhao, Jiajia
Gibb, Leif G
Yoshida, Tomoko
Siciliano, Cody A
Diefenbach, Thomas J
Ramakrishnan, Charu
Deisseroth, Karl
Graybiel, Ann M
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
Ragon Institute of MGH, MIT and Harvard
Friedman, Alexander
Hueske, Emily
Drammis, Sabrina M
Toro Arana, Sebastian E
Nelson, Erik D
Carter, Cody W
Delcasso, Sebastien
Rodriguez, Raimundo X
Lutwak, Hope
DiMarco, Kaden S
Zhang, Qingyang
Rakocevic, Lara I
Hu, Dan
Xiong, Joshua K
Zhao, Jiajia
Gibb, Leif G
Yoshida, Tomoko
Siciliano, Cody A
Diefenbach, Thomas J
Ramakrishnan, Charu
Deisseroth, Karl
Graybiel, Ann M
Source :
PMC
Publication Year :
2021

Abstract

© 2020 Elsevier Inc. Friedman et al. find that specialized regions of the striatum, a key part of the brain's movement and motivation control system, are essential for learning about the values of good and bad outcomes of decisions. The learning signals in striosomes scale according to subjective value and are vulnerable to decline with aging and in neurodegenerative disorders.

Details

Database :
OAIster
Journal :
PMC
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1342474551
Document Type :
Electronic Resource

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