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Antimicrobial Activity of Cathelicidin-Derived Peptide from the Iberian Mole Talpa occidentalis

Authors :
European Commission
Agencia Canaria de Investigación, Innovación y Sociedad de la Información
Caja Canarias
Otazo-Pérez, Andrea [0000-0002-4437-3832]
Asensio-Calavia, Patricia [0000-0001-8413-8426]
González-Acosta, Sergio [0000-0002-6012-8255]
Baca-González, Victoria [0000-0001-7195-7211]
Morales-De la Nuez, Antonio [0000-0002-0184-2037]
Pérez de la Lastra, José Manuel [0000-0003-4663-5565]
Otazo-Pérez, Andrea
Asensio-Calavia, Patricia
González-Acosta, Sergio
Baca-González, Victoria
López, Manuel
Morales-De la Nuez, Antonio
Pérez de Lastra, José Manuel
European Commission
Agencia Canaria de Investigación, Innovación y Sociedad de la Información
Caja Canarias
Otazo-Pérez, Andrea [0000-0002-4437-3832]
Asensio-Calavia, Patricia [0000-0001-8413-8426]
González-Acosta, Sergio [0000-0002-6012-8255]
Baca-González, Victoria [0000-0001-7195-7211]
Morales-De la Nuez, Antonio [0000-0002-0184-2037]
Pérez de la Lastra, José Manuel [0000-0003-4663-5565]
Otazo-Pérez, Andrea
Asensio-Calavia, Patricia
González-Acosta, Sergio
Baca-González, Victoria
López, Manuel
Morales-De la Nuez, Antonio
Pérez de Lastra, José Manuel
Publication Year :
2022

Abstract

The immune systems of all vertebrates contain cathelicidins, a family of antimicrobial peptides. Cathelicidins are a type of innate immune effector that have a number of biological functions, including a well-known direct antibacterial action and immunomodulatory function. In search of new templates for antimicrobial peptide discovery, we have identified and characterized the cathelicidin of the small mammal Talpa occidentalis. We describe the heterogeneity of cathelicidin in the order Eulipotyphla in relation to the Iberian mole and predict its antibacterial activity using bioinformatics tools. In an effort to correlate these findings, we derived the putative active peptide and performed in vitro hemolysis and antimicrobial activity assays, confirming that Iberian mole cathelicidins are antimicrobial. Our results showed that the Iberian mole putative peptide, named To-KL37 (KLFGKVGNLLQKGWQKIKNIGRRIKDFFRNIRPMQEA) has antibacterial and antifungal activity. Understanding the antimicrobial defense of insectivores may help scientists prevent the spread of pathogens to humans. We hope that this study can also provide new, effective antibacterial peptides for future drug development.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1348916065
Document Type :
Electronic Resource