Probability of Stoma in Incident Patients With Crohns Disease in Sweden 2003-2019 : A Population-based Study

Background Surgery rates in patients with Crohns disease have decreased during the last few decades, and use of antitumor necrosis agents (anti-TNF) has increased. Whether these changes correlate with a decreased probability of stoma is unknown. The objective of this study was to investigate the incidence of stoma in patients with Crohns disease over time. Methods Through linkage of national registers, we identified patients who were diagnosed with Crohns disease in 2003-2014 and were followed through 2019. We compared formation and closure of stomas over the calendar periods of diagnosis (2003-2006, 2007-2010, and 2011-2014). Results In a nationwide cohort of 18,815 incident patients with a minimum 5 years of follow-up, 652 (3.5%) underwent formation of a stoma. This was mostly performed in conjunction with ileocolic resection (39%). The 5-year cumulative incidence of stoma formation was 2.5%, with no differences between calendar periods (P = .61). Less than half of the patients (44%) had their stoma reversed. Stomas were more common in elderly-onset compared with pediatric-onset disease: 5-year cumulative incidence 3.6% vs 1.3%. Ileostomies were most common (64%), and 24.5% of the patients who underwent stoma surgery had perianal disease at end of follow-up. Within 5 years of diagnosis, 0.8% of the incident patients had a permanent stoma, and 0.05% had undergone proctectomy. The time from diagnosis to start of anti-TNF treatment decreased over calendar periods (P < .001). Conclusions Despite increasing use of anti-TNF and a low rate of proctectomy, the cumulative incidence of stoma formation within 5 years of Crohns disease diagnosis has not decreased from 2003 to 2019.
Funding Agencies|Karolinska Institutet (KI SOS); Bengt Ihre Research Foundation; Swedish Research Council; Strategic Research Area Epidemiology program at Karolinska Institutet; Stockholm County Council; Karolinska Institutet (ALF); Ostergotland County Council; Linkoping University (ALF); Bengt Ihre Research Fellowship