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Clinical consequences of consecutive self-expanding transcatheter heart valve iterations
- Source :
- Kroon , H G , van Gils , L , Ziviello , F , van Wiechen , M P H , Ooms , J F W , Rahhab , Z , El Faquir , N , Maugenest , A M , Goudzwaard , J A , Cummins , P , Lenzen , M , Kardys , I , Daemen , J , Mattace-Raso , F , de Jaegere , P P T & Van Mieghem , N M 2022 , ' Clinical consequences of consecutive self-expanding transcatheter heart valve iterations ' , Netherlands Heart Journal , vol. 30 , no. 3 , pp. 140-148 .
- Publication Year :
- 2022
-
Abstract
- Objective: To compare early clinical outcomes after transcatheter aortic valve implantation (TAVI) with three consecutive generations of self-expanding valves (SEVs). Methods: Clinical endpoints of consecutive patients who underwent TAVI with CoreValve, Evolut R or Evolut PRO were included in a prospective database. Results: TAVI was performed with CoreValve (n = 116), Evolut R (n = 160) or Evolut PRO (n = 92). Evolut R and Evolut PRO showed a tendency towards lower permanent pacemaker implantation (PPI) rates compared to CoreValve (CoreValve 27% vs Evolut R 16% vs Evolut PRO 18%, p = 0.091). By multivariable regression analysis CoreValve had a significantly higher risk for PPI (odds ratio (OR) 2.79, 95% confidence interval (CI) 1.31–5.94, p = 0.008) compared to Evolut R, while Evolut R and PRO were similar. Severe paravalvular leakage (PVL) occurred only with CoreValve, but no significant difference was observed in moderate PVL (10% vs 8% vs 6%, p = 0.49). CoreValve had a tendency towards a higher risk for more-than-mild PVL as compared with the Evolut platform (R + PRO) (OR 2.46, 95% CI 0.98–6.16, p = 0.055). No significant differences in all-cause mortality (7% vs 4% vs 1%, p = 0.10), stroke (6% vs 3% vs 2%, p = 0.21) or major vascular complications (10% vs 12% vs 4%, p = 0.14) were observed. Conclusions: TAVI with self-expanding valves was safe, and device iterations may result in a lower need for PPI. More-than-mild PVL seemed to occur less often with repositionable technology.
Details
- Database :
- OAIster
- Journal :
- Kroon , H G , van Gils , L , Ziviello , F , van Wiechen , M P H , Ooms , J F W , Rahhab , Z , El Faquir , N , Maugenest , A M , Goudzwaard , J A , Cummins , P , Lenzen , M , Kardys , I , Daemen , J , Mattace-Raso , F , de Jaegere , P P T & Van Mieghem , N M 2022 , ' Clinical consequences of consecutive self-expanding transcatheter heart valve iterations ' , Netherlands Heart Journal , vol. 30 , no. 3 , pp. 140-148 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1352447579
- Document Type :
- Electronic Resource