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Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass

Authors :
Gharibi, Hassan
Chernobrovkin, Alexey L.
Eriksson, Gunilla
Saei, Amir Ata
Timmons, Zena
Kitchener, Andrew C.
Kalthoff, Daniela C.
Lidén, Kerstin
Makarov, Alexander A.
Zubarev, Roman A.
Gharibi, Hassan
Chernobrovkin, Alexey L.
Eriksson, Gunilla
Saei, Amir Ata
Timmons, Zena
Kitchener, Andrew C.
Kalthoff, Daniela C.
Lidén, Kerstin
Makarov, Alexander A.
Zubarev, Roman A.
Publication Year :
2022

Abstract

Analyzing the delta H-2 values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at least 4 times higher delta H-2 than in any previously reported biogenic sample. We ruled out diet as a plausible mechanism for such anomalous enrichment. This finding puts into question the old adage that you are what you eat.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1356420025
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1021.jacs.1c12512