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C6 ceramide (d18:1/6:0) as a novel treatment of cutaneous T cell lymphoma

C6 ceramide (d18:1/6:0) as a novel treatment of cutaneous T cell lymphoma

Authors :
Wilhelm, Raphael
Eckes, Timon Sebastian
Imre, Gergely
Kippenberger, Stefan
Meissner, Markus
Thomas, Dominique Jeanette
Trautmann, Sandra
Merlio, Jean-Philippe
Chevret, Edith
Kaufmann, Roland
Pfeilschifter, Josef
Koch, Alexander
Jäger, Manuel Alexander
Wilhelm, Raphael
Eckes, Timon Sebastian
Imre, Gergely
Kippenberger, Stefan
Meissner, Markus
Thomas, Dominique Jeanette
Trautmann, Sandra
Merlio, Jean-Philippe
Chevret, Edith
Kaufmann, Roland
Pfeilschifter, Josef
Koch, Alexander
Jäger, Manuel Alexander
Publication Year :
2021

Abstract

Cutaneous T cell lymphomas (CTCLs) represent a heterogeneous group of T cell lymphomas that primarily affect the skin. The most frequent forms of CTCL are mycosis fungoides and Sézary syndrome. Both are characterized by frequent recurrence, developing chronic conditions and high mortality with a lack of a curative treatment. In this study, we evaluated the effect of short-chain, cell-permeable C6 Ceramide (C6Cer) on CTCL cell lines and keratinocytes. C6Cer significantly reduced cell viability of CTCL cell lines and induced cell death via apoptosis and necrosis. In contrast, primary human keratinocytes and HaCaT keratinocytes were less affected by C6Cer. Both keratinocyte cell lines showed higher expressions of ceramide catabolizing enzymes and HaCaT keratinocytes were able to metabolize C6Cer faster and more efficiently than CTCL cell lines, which might explain the observed protective effects. Along with other existing skin-directed therapies, C6Cer could be a novel well-tolerated drug for the topical treatment of CTCL.

Details

Database :
OAIster
Notes :
application/octet-stream, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1362826159
Document Type :
Electronic Resource