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Preparation and evaluation of 3,4'-ester derivatives of 16-membered macrolide antibiotics related to tylosin.
- Source :
- Journal of antibiotics, 39 (12
- Publication Year :
- 1986
-
Abstract
- A large group of ester derivatives of tylosin-related macrolides was prepared in which the hydroxyl groups at C-3 and C-4'' were acylated by either chemical or biochemical methods. Most of the derivatives exhibited excellent in vitro antimicrobial activity. However, only the 3,4''-diacyl derivatives of tylosin and macrocin showed any significant improvements of in vivo efficacy against experimental infections in rodents.<br />info:eu-repo/semantics/published
Details
- Database :
- OAIster
- Journal :
- Journal of antibiotics, 39 (12
- Notes :
- No full-text files, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1363692955
- Document Type :
- Electronic Resource