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Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial

Authors :
Universidad de Sevilla. Departamento de Medicina
Universidad de Sevilla. CT406. Estudio de enfermedades infecciosas en la práctica clínica
ISCIII-Subdirección General de Evaluación y Fomento de la Investigación
Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia, Industria y Competitividad
Rodríguez-Pardo, Dolors
Toro López, María Dolores del
Guío-Carrión, Laura
Escudero-Sánchez, Rosa
Fernández-Sampedro, Marta
García-Viejo, Miguel Ángel
Pigrau, Carles
Universidad de Sevilla. Departamento de Medicina
Universidad de Sevilla. CT406. Estudio de enfermedades infecciosas en la práctica clínica
ISCIII-Subdirección General de Evaluación y Fomento de la Investigación
Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministerio de Economia, Industria y Competitividad
Rodríguez-Pardo, Dolors
Toro López, María Dolores del
Guío-Carrión, Laura
Escudero-Sánchez, Rosa
Fernández-Sampedro, Marta
García-Viejo, Miguel Ángel
Pigrau, Carles
Publication Year :
2021

Abstract

Purpose To evaluate preoperative asymptomatic bacteriuria (ASB) treatment to reduce early-periprosthetic joint infections (early-PJIs) after hip hemiarthroplasty (HHA) for fracture. Methods Open-label, multicenter RCT comparing fosfomycin-trometamol versus no intervention with a parallel follow-up cohort without ASB. Primary outcome: early-PJI after HHA. Results Five hundred ninety-four patients enrolled (mean age 84.3); 152(25%) with ASB (77 treated with fosfomycin trometamol/75 controls) and 442(75%) without. Despite the study closed without the intended sample size, ASB was not predictive of early-PJI (OR: 1.06 [95%CI: 0.33–3.38]), and its treatment did not modify early-PJI incidence (OR: 1.03 [95%CI: 0.15–7.10]). Conclusions Neither preoperative ASB nor its treatment appears to be risk factors of early-PJI after HHA. ClinicalTrials.gov Identifier: Eudra CT 2016-001108-47

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1367140849
Document Type :
Electronic Resource