Spontaneous hyphema in the setting of COVID-19 pneumonia.

PurposeTo report a challenging case of spontaneous hyphema in the setting of prone positioning for COVID-19 pneumonia.ObservationsA previously healthy patient was concomitantly diagnosed with acute myelogenous leukemia (AML) and COVID-19 infection. During his hospitalization he required intubation and prone positioning. Following change from prone to supine positioning, he was noted to have developed a large unilateral spontaneous hyphema.Conclusions and importanceWe present a challenging case of spontaneous hyphema due to a hematologic malignancy in the setting of prone positioning for COVID-19 pneumonia.