Back to Search
Start Over
Production of a T cell hybridoma that expresses the T cell receptor gamma/delta heterodimer.
- Source :
- The Journal of experimental medicine; vol 165, iss 6, 1725-1730; 0022-1007
- Publication Year :
- 1987
-
Abstract
- We have produced a T cell hybridoma line by fusion of an IL-2-dependent, long-term T cell receptor (TCR) gamma/delta+ Thy-1+, bone marrow-derived, dendritic epidermal cell line to the BW5147 tumor line. The resultant hybridoma was rapidly growing, lymphokine independent, and expressed T3 in association with the TCR gamma/delta heterodimer. Several subclones of the hybridoma line produced easily detectable levels of IL-2 after stimulation by anti-T3 or Con A. The availability of these cloned cell lines should greatly facilitate further functional, biochemical, and molecular studies of the TCR delta chain.
Details
- Database :
- OAIster
- Journal :
- The Journal of experimental medicine; vol 165, iss 6, 1725-1730; 0022-1007
- Notes :
- application/pdf, The Journal of experimental medicine vol 165, iss 6, 1725-1730 0022-1007
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1367439550
- Document Type :
- Electronic Resource