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Phage-tail-like bacteriocins as a biomedical platform to counter anti-microbial resistant pathogens

Authors :
Bhattacharjee, Rahul
Nandi, Aditya
Sinha, Adrija
Kumar, Hrithik
Mitra, Disha
Mojumdar, Abhik
Patel, Paritosh
Jha, Ealisha
Mishra, Suman
Rout, Prabhat Kumar
Panda, Pritam Kumar
Suar, Mrutyunjay
Verma, Suresh K.
Bhattacharjee, Rahul
Nandi, Aditya
Sinha, Adrija
Kumar, Hrithik
Mitra, Disha
Mojumdar, Abhik
Patel, Paritosh
Jha, Ealisha
Mishra, Suman
Rout, Prabhat Kumar
Panda, Pritam Kumar
Suar, Mrutyunjay
Verma, Suresh K.
Publication Year :
2022

Abstract

Phage Tail Like bacteriocins (PTLBs) has been an area of interest in the last couple of years owing to their varied application against multi-drug resistant (MDR), anti-microbial resistant (AMR) pathogens and their evolutionary link with the dsDNA virus and bacteriophages. PTLBs are defective phages derived from Myoviridae and Sipho-viridae phages, PTLBs are distinguished into R-type (Rigid type) characterized by a non-flexible contractile nanotube resembling Myoviridae phage contractile tails, and F-type (Flexible type) with a flexible non-contractile rod-like structure similar to Siphoviridae phages. In this review, we have discussed the structural association, mechanism, and characterization of PTLBs. Moreover, we have elucidated the symbiotic biological function and application of PTLBs against MDR and XDR pathogens and highlighted the evolutionary role of PTLBs. The difficulties that must be overcome to implement PTLBs clinically are also discussed. It is imperative that these issues be addressed by academics in future studies before being implemented in clinical settings. This article is novel in its way as it will not only provide us with a gateway that acts as a novel strategy for scholars to mitigate and control the uprising issue of AMR pathogens but also promote the development of clinical studies for PTLBs.

Details

Database :
OAIster
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1372241306
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1016.j.biopha.2022.113720