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Autoimmune pulmonary alveolar proteinosis co-existing with breast cancer: a case report

Authors :
Sawai, Toyomitsu
Umeyama, Yasuhiro
Yoshioka, Sumako
Matsuo, Nobuko
Suyama, Naofumi
Kohno, Shigeru
Sawai, Toyomitsu
Umeyama, Yasuhiro
Yoshioka, Sumako
Matsuo, Nobuko
Suyama, Naofumi
Kohno, Shigeru
Publication Year :
2014

Abstract

Introduction. Pulmonary alveolar proteinosis is a rare pulmonary disease characterized by excessive alveolar accumulation of surfactant due to defective alveolar clearance by macrophages. There are only a few published case reports of pulmonary alveolar proteinosis occurring in association with solid cancers. To the best of our knowledge, there are no previously reported cases of pulmonary alveolar proteinosis associated with breast cancer. Case presentation. A 48-year-old Asian woman, a nonsmoker, presented to our institution with a right breast mass. Biopsy examination of the lesion revealed scirrhous carcinoma. A chest computed tomography scan for metastases showed abnormal shadows in both upper lung fields. As a result of flexible fiberscopic bronchoscopy, this patient was diagnosed as having pulmonary alveolar proteinosis. This case was categorized as autoimmune pulmonary alveolar proteinosis due to the positive anti-granulocyte-macrophage colony-stimulating factor antibody. Pulmonary alveolar proteinosis decreased gradually after mastectomy. Conclusions: The present case involved the coincident occurrence of autoimmune pulmonary alveolar proteinosis with breast cancer; breast cancer may be a factor during pulmonary alveolar proteinosis development.<br />Journal of Medical Case Reports, 8(1), 279; 2014

Details

Database :
OAIster
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1375206113
Document Type :
Electronic Resource