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Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
- Source :
- Young , W J , Haessler , J , Benjamins , J W , Repetto , L , Yao , J , Isaacs , A , Harper , A R , Ramirez , J , Garnier , S , van Duijvenboden , S , Baldassari , A R , Concas , M P , Duong , T V , Foco , L , Isaksen , J L , Mei , H , Noordam , R , Nursyifa , C , Richmond , A , Santolalla , M L , Sitlani , C M , Soroush , N , Thériault , S , Trompet , S , Aeschbacher , S , Ahmadizar , F , Alonso , A , Brody , J A , Campbell , A , Correa , A , Darbar , D , De Luca , A , Deleuze , J F , Ellervik , C , Fuchsberger , C , Goel , A , Grace , C , Guo , X , Hansen , T , Heckbert , S R , Jackson , R D , Kors , J A , Lima-Costa , M F , Linneberg , A , Macfarlane , P W , Morrison , A C , Navarro , P , Porteous , D J , Pramstaller , P P , Reiner , A P , Risch , L , Schotten , U , Shen , X , Sinagra , G , Soliman , E Z , Stoll , M , Tarazona-Santos , E , Tinker , A , Trajanoska , K , Villard , E , Warren , H R , Whitsel , E A , Wiggins , K L , Arking , D E , Avery , C L , Conen , D , Girotto , G , Grarup , N , Hayward , C , Jukema , J W , Mook-Kanamori , D O , Olesen , M S , Padmanabhan , S , Psaty , B M , Pattaro , C , Ribeiro , A L P , Rotter , J I , Stricker , B H , van der Harst , P , van Duijn , C M , Verweij , N , Wilson , J G , Orini , M , Charron , P , Watkins , H , Kooperberg , C , Lin , H J , Wilson , J F , Kanters , J K , Sotoodehnia , N , Mifsud , B , Lambiase , P D , Tereshchenko , L G & Munroe , P B 2023 , ' Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease ' , Nature Communications , vol. 14 , no. 1 , 1411 .
- Publication Year :
- 2023
-
Abstract
- The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.
Details
- Database :
- OAIster
- Journal :
- Young , W J , Haessler , J , Benjamins , J W , Repetto , L , Yao , J , Isaacs , A , Harper , A R , Ramirez , J , Garnier , S , van Duijvenboden , S , Baldassari , A R , Concas , M P , Duong , T V , Foco , L , Isaksen , J L , Mei , H , Noordam , R , Nursyifa , C , Richmond , A , Santolalla , M L , Sitlani , C M , Soroush , N , Thériault , S , Trompet , S , Aeschbacher , S , Ahmadizar , F , Alonso , A , Brody , J A , Campbell , A , Correa , A , Darbar , D , De Luca , A , Deleuze , J F , Ellervik , C , Fuchsberger , C , Goel , A , Grace , C , Guo , X , Hansen , T , Heckbert , S R , Jackson , R D , Kors , J A , Lima-Costa , M F , Linneberg , A , Macfarlane , P W , Morrison , A C , Navarro , P , Porteous , D J , Pramstaller , P P , Reiner , A P , Risch , L , Schotten , U , Shen , X , Sinagra , G , Soliman , E Z , Stoll , M , Tarazona-Santos , E , Tinker , A , Trajanoska , K , Villard , E , Warren , H R , Whitsel , E A , Wiggins , K L , Arking , D E , Avery , C L , Conen , D , Girotto , G , Grarup , N , Hayward , C , Jukema , J W , Mook-Kanamori , D O , Olesen , M S , Padmanabhan , S , Psaty , B M , Pattaro , C , Ribeiro , A L P , Rotter , J I , Stricker , B H , van der Harst , P , van Duijn , C M , Verweij , N , Wilson , J G , Orini , M , Charron , P , Watkins , H , Kooperberg , C , Lin , H J , Wilson , J F , Kanters , J K , Sotoodehnia , N , Mifsud , B , Lambiase , P D , Tereshchenko , L G & Munroe , P B 2023 , ' Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease ' , Nature Communications , vol. 14 , no. 1 , 1411 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1376785662
- Document Type :
- Electronic Resource