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[18F]FDG PET/CT: Lung Nodule Evaluation in Patients Affected by Renal Cell Carcinoma

Authors :
Airo Farulla, L
Travaini, L
Cuomo, M
Galetta, D
Mattana, F
Frassoni, S
Buonsanti, G
Muraglia, L
Zuccotti, G
Bagnardi, V
Spaggiari, L
Ceci, F
Airo Farulla L. S.
Travaini L. L.
Cuomo M.
Galetta D.
Mattana F.
Frassoni S.
Buonsanti G.
Muraglia L.
Zuccotti G. A.
Bagnardi V.
Spaggiari L.
Ceci F.
Airo Farulla, L
Travaini, L
Cuomo, M
Galetta, D
Mattana, F
Frassoni, S
Buonsanti, G
Muraglia, L
Zuccotti, G
Bagnardi, V
Spaggiari, L
Ceci, F
Airo Farulla L. S.
Travaini L. L.
Cuomo M.
Galetta D.
Mattana F.
Frassoni S.
Buonsanti G.
Muraglia L.
Zuccotti G. A.
Bagnardi V.
Spaggiari L.
Ceci F.
Publication Year :
2023

Abstract

Renal Cell Carcinoma (RCC) is generally characterized by low-FDG avidity, and [18F]FDG-PET/CT is not recommended to stage the primary tumor. However, its role to assess metastases is still unclear. The aim of this study was to evaluate the diagnostic accuracy of [18F]FDG-PET/CT in correctly identifying RCC lung metastases using histology as the standard of truth. The records of 350 patients affected by RCC were retrospectively analyzed. The inclusion criteria were: (a) biopsy- or histologically proven RCC; (b) Computed Tomography (CT) evidence of at least one lung nodule; (c) [18F]FDG-PET/CT performed prior to lung surgery; (d) lung surgery with histological analysis of surgical specimens; (e) complete follow-up available. A per-lesion analysis was performed, and diagnostic accuracy was reported as sensitivity and specificity, using histology as the standard of truth. [18F]FDG-PET/CT semiquantitative parameters (Standardized Uptake Value [SUVmax], Metabolic Tumor Volume [MTV] and Total Lesion Glycolysis [TLG]) were collected for each lesion. Sixty-seven patients with a total of 107 lesions were included: lung metastases from RCC were detected in 57 cases (53.3%), while 50 lesions (46.7%) were related to other lung malignancies. Applying a cut-off of SUVmax ≥ 2, the sensitivity and the specificity of [18F]FDG-PET/CT in detecting RCC lung metastases were 33.3% (95% CI: 21.4–47.1%) and 26% (95%CI: 14.6–40.3%), respectively. Although the analysis demonstrated a suboptimal diagnostic accuracy of [18F]FDG-PET/CT in discriminating between lung metastases from RCC and other malignancies, a semiquantitative analysis that also includes volumetric parameters (MTV and TLG) could support the correct interpretation of [18F]FDG-PET/CT images.

Details

Database :
OAIster
Notes :
ELETTRONICO, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1376787921
Document Type :
Electronic Resource