Sorry, I don't understand your search. ×
Back to Search Start Over

On the toxicity of e-cigarettes consumption: Focus on pathological cellular mechanisms

Authors :
Ministerio de Ciencia, Innovación y Universidades (España)
Ministero dell'Istruzione, dell'Università e della Ricerca
Junta de Andalucía
Vivarelli, Fabio
Granata, Silvia
Rullo, Laura
Mussoni, Matilde
Candeletti, Sanzio
Romualdi, Patrizia
Fimognari, Carmela
Cruz-Chamorro, Iván
Carrillo-Vico, Antonio
Paolini, Moreno
Canistro, Donatella
Ministerio de Ciencia, Innovación y Universidades (España)
Ministero dell'Istruzione, dell'Università e della Ricerca
Junta de Andalucía
Vivarelli, Fabio
Granata, Silvia
Rullo, Laura
Mussoni, Matilde
Candeletti, Sanzio
Romualdi, Patrizia
Fimognari, Carmela
Cruz-Chamorro, Iván
Carrillo-Vico, Antonio
Paolini, Moreno
Canistro, Donatella
Publication Year :
2022

Abstract

Tobacco smoking remains without a doubt one of the leading causes of premature death worldwide. In combination with conventional protocols for smoking cessation, e-cigarettes have been proposed as a useful tool to quit smoking. Advertised as almost free of toxic effects, e-cigarettes have rapidly increased their popularity, becoming a sought-after device, especially among young people. Recently some health concerns about e-cigarette consumption are being raised. It is well known that they can release several toxic compounds, some of which are carcinogenic to humans, and emerging results are now outlining the risks related to the onset of respiratory and cardiovascular diseases and even cancer. The present review shows the emerging evidence about the role of technical components of the devices, the e-liquid composition as well as customization by consumers. The primary topics we discuss are the main toxicological aspects associated with e-cigarette consumption, focusing on the molecular pathways involved. Here it will be shown how exposure to e-cigarette aerosol induces stress/mitochondrial toxicity, DNA breaks/fragmentation following the same pathological pathways triggered by tobacco smoke, including the deregulation of molecular signalling axis associated with cancer progression and cell migration. Risk to fertility and pregnancy, as well as cardiovascular risk associated with e-cigarette use, have also been reported.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1380454694
Document Type :
Electronic Resource