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Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events:the ECHOVID-19 study
- Source :
- Skaarup , K G , Lassen , M C H , Espersen , C , Lind , J N , Johansen , N D , Sengeløv , M , Alhakak , A S , Nielsen , A B , Ravnkilde , K , Hauser , R , Schops , L B , Holt , E , Bundgaard , H , Hassager , C , Jabbari , R , Carlsen , J , Kirk , O , Bodtger , U , Lindholm , M G , Wiese , L , Kristiansen , O P , Walsted , E S , Nielsen , O W , Lindegaard , B , Tonder , N , Jeschke , K N , Ulrik , C S , Lamberts , M , Sivapalan , P , Pallisgaard , J , Gislason , G , Iversen , K , Jensen , J U S , Schou , M , Skaarup , S H , Platz , E & Biering-Sorensen , T 2022 , ' Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events : the ECHOVID-19 study ' , Journal of Ultrasound , vol. 25 , pp. 457–467 .
- Publication Year :
- 2022
-
Abstract
- Purpose Several studies have reported thromboembolic events to be common in severe COVID-19 cases. We sought to investigate the relationship between lung ultrasound (LUS) findings in hospitalized COVID-19 patients and the development of venous thromboembolic events (VTE). Methods A total of 203 adults were included from a COVID-19 ward in this prospective multi-center study (mean age 68.6 years, 56.7% men). All patients underwent 8-zone LUS, and all ultrasound images were analyzed off-line blinded. Several LUS findings were investigated (total number of B-lines, B-line score, and LUS-scores). Results Median time from admission to LUS examination was 4 days (IQR: 2, 8). The median number of B-lines was 12 (IQR: 8, 18), and 44 (21.7%) had a positive B-line score. During hospitalization, 17 patients developed VTE (4 deep-vein thrombosis, 15 pulmonary embolism), 12 following and 5 prior to LUS. In fully adjusted multivariable Cox models (excluding participants with VTE prior to LUS), all LUS parameters were significantly associated with VTE (total number of B-lines: HR = 1.14, 95% CI (1.03, 1.26) per 1 B-line increase), positive B-line score: HR = 9.79, 95% CI (1.87, 51.35), and LUS-score: HR = 1.51, 95% CI (1.10, 2.07), per 1-point increase). The B-line score and LUS-score remained significantly associated with VTE in sensitivity analyses. Conclusion In hospitalized COVID-19 patients, pathological LUS findings were common, and the total number of B-lines, B-line score, and LUS-score were all associated with VTE. These findings indicate that the LUS examination may be useful in risk stratification and the clinical management of COVID-19. These findings should be considered hypothesis generating. Clinicaltrials.gov ID NCT04377035
Details
- Database :
- OAIster
- Journal :
- Skaarup , K G , Lassen , M C H , Espersen , C , Lind , J N , Johansen , N D , Sengeløv , M , Alhakak , A S , Nielsen , A B , Ravnkilde , K , Hauser , R , Schops , L B , Holt , E , Bundgaard , H , Hassager , C , Jabbari , R , Carlsen , J , Kirk , O , Bodtger , U , Lindholm , M G , Wiese , L , Kristiansen , O P , Walsted , E S , Nielsen , O W , Lindegaard , B , Tonder , N , Jeschke , K N , Ulrik , C S , Lamberts , M , Sivapalan , P , Pallisgaard , J , Gislason , G , Iversen , K , Jensen , J U S , Schou , M , Skaarup , S H , Platz , E & Biering-Sorensen , T 2022 , ' Lung ultrasound findings in hospitalized COVID-19 patients in relation to venous thromboembolic events : the ECHOVID-19 study ' , Journal of Ultrasound , vol. 25 , pp. 457–467 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1382508877
- Document Type :
- Electronic Resource