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Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis

Authors :
Olesen, Caroline M.
Clausen, Maja Lisa
Agner, Tove
Asplund, Maria
Rasmussen, Linett
Yüksel, Yasemine T.
Andersen, Paal S.
Litman, Thomas
Hansen, Anders J.
Barnes, Christopher J.
Olesen, Caroline M.
Clausen, Maja Lisa
Agner, Tove
Asplund, Maria
Rasmussen, Linett
Yüksel, Yasemine T.
Andersen, Paal S.
Litman, Thomas
Hansen, Anders J.
Barnes, Christopher J.
Source :
Olesen , C M , Clausen , M L , Agner , T , Asplund , M , Rasmussen , L , Yüksel , Y T , Andersen , P S , Litman , T , Hansen , A J & Barnes , C J 2022 , ' Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis ' , Acta Dermato-Venereologica , vol. 102 , adv00817 .
Publication Year :
2022

Abstract

The aim of this study was to investigate the early-life development of the skin microbiome in atopic derma-titis. Nineteen infants with atopic dermatitis and 19 healthy infants were evaluated 3 times, at 3 months intervals, within the first 30 months of life. Tape-strips were collected from volar forearms, cheeks, and ec-zema lesions, and the skin microbiome was assessed by 16S rRNA sequencing. Both the community struc-ture and richness of the skin microbiome of infants with atopic dermatitis differed significantly from that of healthy infants, with greater richness in healthy infants. For infants with atopic dermatitis, the community composition was not dominated by Staphylo-cocci. For healthy infants, community composition and richness correlated significantly with age, while such a pattern was not revealed in infants with atopic der-matitis. This suggests a slower maturation of the skin microbiome in atopic dermatitis, which precedes the staphylococcal predominance observed in older children and adults.

Details

Database :
OAIster
Journal :
Olesen , C M , Clausen , M L , Agner , T , Asplund , M , Rasmussen , L , Yüksel , Y T , Andersen , P S , Litman , T , Hansen , A J & Barnes , C J 2022 , ' Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis ' , Acta Dermato-Venereologica , vol. 102 , adv00817 .
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1382512785
Document Type :
Electronic Resource