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Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism
- Source :
- Rodprasert , W , Koskenniemi , J J , Virtanen , H E , Sadov , S , Perheentupa , A , Ollila , H , Albrethsen , J , Andersson , A-M , Juul , A , Skakkebaek , N E , Main , K M & Toppari , J 2022 , ' Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism ' , The Journal of clinical endocrinology and metabolism , vol. 107 , no. 12 , pp. 3353-3361 .
- Publication Year :
- 2022
-
Abstract
- CONTEXT: Longitudinal data on levels of hypothalamic-pituitary-gonadal axis hormones and insulin-like growth factor I (IGF-I) during puberty in boys with a history of cryptorchidism are largely missing.OBJECTIVE: We aimed to compare pubertal hormone levels between boys with a history of congenital cryptorchidism who experienced spontaneous testicular descent or underwent orchiopexy and boys without a history of cryptorchidism.METHODS: This was a nested case-control study within a population-based birth cohort, with a prospective, longitudinal pubertal follow-up every 6 months (2005 to 2019). Participants were 109 Finnish boys, including boys with a history of unilateral cryptorchidism who underwent orchiopexy (n = 15), unilateral cryptorchidism who had spontaneous testicular descent (n = 15), bilateral cryptorchidism who underwent orchiopexy (n = 9), bilateral cryptorchidism who had spontaneous testicular descent (n = 7), and controls (n = 63). Serum reproductive hormone levels and testicular volumes were measured.RESULTS: From around onset of puberty, boys with bilateral cryptorchidism who underwent orchiopexy had significantly higher follicle-stimulating hormone (FSH) and lower inhibin B levels than controls. Boys with unilateral cryptorchidism who underwent orchiopexy had significantly higher FSH than controls, whereas inhibin B levels were similar. Testosterone, luteinizing hormone, insulin-like factor 3, and IGF-I were generally similar between groups. Testicular volume of boys with unilateral or bilateral cryptorchidism who underwent orchiopexy was smaller than that of the controls from 1 year after pubertal onset (P < 0.05).CONCLUSION: Cryptorchid boys, particularly those with bilateral cryptorchidism who underwent orchiopexy, had altered levels of serum biomarkers of Sertoli cells and germ cells and smaller testicular volumes compared with controls.
Details
- Database :
- OAIster
- Journal :
- Rodprasert , W , Koskenniemi , J J , Virtanen , H E , Sadov , S , Perheentupa , A , Ollila , H , Albrethsen , J , Andersson , A-M , Juul , A , Skakkebaek , N E , Main , K M & Toppari , J 2022 , ' Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism ' , The Journal of clinical endocrinology and metabolism , vol. 107 , no. 12 , pp. 3353-3361 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1382520011
- Document Type :
- Electronic Resource