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Controversies in the Interpretation of Liquid Biopsy Data in Lymphoma

Authors :
Pirosa, Maria Cristina
Borchmann, Sven
Jardin, Fabrice
Gaidano, Gianluca
Rossi, Davide
Pirosa, Maria Cristina
Borchmann, Sven
Jardin, Fabrice
Gaidano, Gianluca
Rossi, Davide
Publication Year :
2022

Abstract

The rapid evolution of genomic technologies over the last years has led to the development of different methods for the detection, measurement and analysis of cell-free DNA fragments (cfDNA) which are shed into the bloodstream by apoptotic cells and circulate at a low concentration in plasma. In cancer patients, the proportion of tumor-derived cfDNA is defined as circulating tumor DNA. This analysis, commonly known as liquid biopsy, allows to access tumor DNA through a simple blood sampling and therefore without the need of an invasive tissue biopsy. For this reason, this tool may have several clinical applications in terms of diagnosis, prognosis, and monitoring of minimal residual disease. However, there are still several critical issues that need to be resolved. In this review, we will discuss some of the controversies around this method and its potential clinical applications.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1383743836
Document Type :
Electronic Resource