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Invasiveness of Ventilation Therapy Is Associated to Prevalence of Secondary Bacterial and Fungal Infections in Critically Ill COVID-19 Patients

Authors :
de Hesselle, Marie Louise
Borgmann, Stefan
Rieg, Siegbert
Vehreshild, Jorg Janne
Spinner, Christoph D.
Koll, Carolin E. M.
Hower, Martin
Stecher, Melanie
Ebert, Daniel
Hanses, Frank
Schumann, Julia
de Hesselle, Marie Louise
Borgmann, Stefan
Rieg, Siegbert
Vehreshild, Jorg Janne
Spinner, Christoph D.
Koll, Carolin E. M.
Hower, Martin
Stecher, Melanie
Ebert, Daniel
Hanses, Frank
Schumann, Julia
Publication Year :
2022

Abstract

Superinfections are a fundamental critical care problem, and their significance in severe COVID-19 cases needs to be determined. This study analyzed data from the Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort focusing on intensive care patients. A retrospective analysis of patient data from 840 cases of COVID-19 with critical courses demonstrated that co-infections were frequently present and were primarily of nosocomial origin. Furthermore, our analysis showed that invasive therapy procedures accompanied an increased risk for healthcare-associated infections. Non-ventilated ICU patients were rarely affected by secondary infections. The risk of infection, however, increased even when non-invasive ventilation was used. A further, significant increase in infection rates was seen with the use of invasive ventilation and even more so with extracorporeal membrane oxygenation (ECMO) therapy. The marked differences among ICU techniques used for the treatment of COVID-19-induced respiratory failure in terms of secondary infection risk profile should be taken into account for the optimal management of critically ill COVID-19 patients, as well as for adequate antimicrobial therapy.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1383744639
Document Type :
Electronic Resource