Violacein enhances the cytotoxic effect of commonly used chemotherapeutics on rhabdomyosarcoma cells

Investigati on of natural compounds showing specific toxicity to tumor cells aims to improve the efficacy of available therapies. Our previous research demonstrated the cytotoxic acti vity of the bacterial pigment violacein against rhabdomyosarcoma (RMS) cell lines. RMS is the most common soft tissue malignancy in children. In this study, we evaluated the cytotoxicity of violacein on RMS cells in combinati on with conventi onal chemotherapeutics doxorubicin, irinotecan, and vinflunine.