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Requirement for CD40 ligand, CD4(+) T cells, and B cells in an infectious mononucleosis-like syndrome
- Source :
- Brooks , J W , Hamilton-Easton , A M , Christensen , J P , Christensen , J P , Cardin , R D , Hardy , C L & Doherty , P C 1999 , ' Requirement for CD40 ligand, CD4(+) T cells, and B cells in an infectious mononucleosis-like syndrome ' , Journal of Virology , vol. 73 , no. 11 , pp. 9650-4 .
- Publication Year :
- 1999
-
Abstract
- Udgivelsesdato: 1999-Nov<br />Respiratory challenge with the murine gammaherpesvirus 68 (gammaHV-68) results in productive infection of the lung, the establishment of latency in B lymphocytes and other cell types, transient splenomegaly, and prolonged clonal expansion of activated CD8(+) CD62L(lo) T cells, particularly a Vbeta4(+) CD8(+) population that is found in mice with different major histocompatibility complex (MHC) haplotypes. Aspects of the CD8(+)-T-cell response are substantially modified in mice that lack B cells, CD4(+) T cells, or the CD40 ligand (CD40L). The B-cell-deficient mice show no increase in Vbeta4(+) CD8(+) T cells. Similar abrogation of the Vbeta4(+) CD8(+) response is seen following antibody-mediated depletion of the CD4(+) subset, through the numbers of CD8(+) CD62L(lo) cells are still significantly elevated. Virus-specific CD4(+)-T-cell frequencies are minimal in the CD40L(-/-) mice, and the Vbeta4(+) CD8(+) population remains unexpanded. Apparently B-cell-CD4(+)-T-cell interactions play a part in the gammaHV-68 induction of both splenomegaly and non-MHC-restricted Vbeta4(+) CD8(+)-T-cell expansion.
Details
- Database :
- OAIster
- Journal :
- Brooks , J W , Hamilton-Easton , A M , Christensen , J P , Christensen , J P , Cardin , R D , Hardy , C L & Doherty , P C 1999 , ' Requirement for CD40 ligand, CD4(+) T cells, and B cells in an infectious mononucleosis-like syndrome ' , Journal of Virology , vol. 73 , no. 11 , pp. 9650-4 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1407892331
- Document Type :
- Electronic Resource