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Synthesis of Some New Heteroarylamino-3-Nitro-2H-[1]-Benzopyran-2-ones and their Antibacterial Activity
- Source :
- American Scientific Research Journal for Engineering, Technology, and Sciences; Vol. 22 No. 1 (2016); 1-9; 2313-4402; 2313-4410
- Publication Year :
- 2016
-
Abstract
- Novel derivatives of benzopyran-2-ones are synthesized by catalytic condensation reaction. 4-(3-Hydroxy-2-pyridinylamino)- 3-nitro-2H-[1]-benzopyran-2-one 4a, 4-(4-methyl-3-nitro-2-pyridinylamino)-3-nitro-2H-[1]-benzopyran-2-one, 4b and 4-(pyrimidinylamono)-3-nitro-2H-[1]-benzopyran-2-ones 4(c, d) are synthesized by condensation of 4-Chlor-3-nitro-2H-[1]-benzopyran-2-one 2 and corresponding heteroarylamines 3(a-d ) under reflux reaction conditions. Alkali hydrolysis of 4(a-d ) afforded the 2-hydroxy-? -nitroacetophenone 5. Structural characterization of the synthesized products is done on the basis of spectrometric data. Antibacterial activity of the compounds 4(a-d) against S. aureus, E. coli and Klebsiella was examined by measuring the inhibition zones around the disks marked with the corresponding product solutions in N,N-DMF concentration 2 mg/mL , 4 mg/mL and 6 mg/mL. Compounds 4a and 4c have shown significant antibacterial activity against S. aureus, compounds 4b and 4d exhibited significant activity against E. coli whereas compound 4d was more active against Klebsiella.
Details
- Database :
- OAIster
- Journal :
- American Scientific Research Journal for Engineering, Technology, and Sciences; Vol. 22 No. 1 (2016); 1-9; 2313-4402; 2313-4410
- Notes :
- application/pdf, application/vnd.openxmlformats-officedocument.wordprocessingml.document, application/vnd.openxmlformats-officedocument.wordprocessingml.document, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1408122379
- Document Type :
- Electronic Resource