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Synthesis of Some New Heteroarylamino-3-Nitro-2H-[1]-Benzopyran-2-ones and their Antibacterial Activity

Authors :
Hoti, Ramiz
Vehapi, Idriz
Mulliqi-Osmani, Gjyle
Ismaili, Hamit
Thaci, Veprim
Hoti, Ramiz
Vehapi, Idriz
Mulliqi-Osmani, Gjyle
Ismaili, Hamit
Thaci, Veprim
Source :
American Scientific Research Journal for Engineering, Technology, and Sciences; Vol. 22 No. 1 (2016); 1-9; 2313-4402; 2313-4410
Publication Year :
2016

Abstract

Novel derivatives of benzopyran-2-ones are synthesized by catalytic condensation reaction. 4-(3-Hydroxy-2-pyridinylamino)- 3-nitro-2H-[1]-benzopyran-2-one 4a, 4-(4-methyl-3-nitro-2-pyridinylamino)-3-nitro-2H-[1]-benzopyran-2-one, 4b and 4-(pyrimidinylamono)-3-nitro-2H-[1]-benzopyran-2-ones 4(c, d) are synthesized by condensation of 4-Chlor-3-nitro-2H-[1]-benzopyran-2-one 2 and corresponding heteroarylamines 3(a-d ) under reflux reaction conditions. Alkali hydrolysis of 4(a-d ) afforded the 2-hydroxy-? -nitroacetophenone 5. Structural characterization of the synthesized products is done on the basis of spectrometric data. Antibacterial activity of the compounds 4(a-d) against S. aureus, E. coli and Klebsiella was examined by measuring the inhibition zones around the disks marked with the corresponding product solutions in N,N-DMF concentration 2 mg/mL , 4 mg/mL and 6 mg/mL. Compounds 4a and 4c have shown significant antibacterial activity against S. aureus, compounds 4b and 4d exhibited significant activity against E. coli whereas compound 4d was more active against Klebsiella.

Details

Database :
OAIster
Journal :
American Scientific Research Journal for Engineering, Technology, and Sciences; Vol. 22 No. 1 (2016); 1-9; 2313-4402; 2313-4410
Notes :
application/pdf, application/vnd.openxmlformats-officedocument.wordprocessingml.document, application/vnd.openxmlformats-officedocument.wordprocessingml.document, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1408122379
Document Type :
Electronic Resource