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Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors.
- Source :
- Science; vol 356, iss 6335
- Publication Year :
- 2017
-
Abstract
- Dendritic cells (DCs) and monocytes play a central role in pathogen sensing, phagocytosis, and antigen presentation and consist of multiple specialized subtypes. However, their identities and interrelationships are not fully understood. Using unbiased single-cell RNA sequencing (RNA-seq) of ~2400 cells, we identified six human DCs and four monocyte subtypes in human blood. Our study reveals a new DC subset that shares properties with plasmacytoid DCs (pDCs) but potently activates T cells, thus redefining pDCs; a new subdivision within the CD1C+ subset of DCs; the relationship between blastic plasmacytoid DC neoplasia cells and healthy DCs; and circulating progenitor of conventional DCs (cDCs). Our revised taxonomy will enable more accurate functional and developmental analyses as well as immune monitoring in health and disease.
Details
- Database :
- OAIster
- Journal :
- Science; vol 356, iss 6335
- Notes :
- application/pdf, Science vol 356, iss 6335
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1410328877
- Document Type :
- Electronic Resource