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A blended preconception lifestyle programme for couples undergoing IVF: lessons learned from a multicentre randomized controlled trial

Authors :
Boedt, T.
Dancet, E.
de Neubourg, D.
Vereeck, S.
Seghers, J.
van der Gucht, K.
van Calster, B.
Spiessens, C.
Lie Fong, S.
Matthys, C.
Boedt, T.
Dancet, E.
de Neubourg, D.
Vereeck, S.
Seghers, J.
van der Gucht, K.
van Calster, B.
Spiessens, C.
Lie Fong, S.
Matthys, C.
Source :
Human Reproduction vol.2023 (2023) nr.4 [ISSN 0268-1161]
Publication Year :
2023

Abstract

Study question: What is the effect of a blended preconception lifestyle programme on reproductive and lifestyle outcomes of couples going through their first 12 months of IVF as compared to an attention control condition? Summery answer: This randomized controlled trial (RCT) was stopped prematurely because of the coronavirus disease 2019 (Covid-19) pandemic but the available data did not suggest that a blended preconception lifestyle programme could meaningfully affect time to ongoing pregnancy or other reproductive and lifestyle outcomes. What is know already: Increasing evidence shows associations between a healthy lifestyle and IVF success rates. Lifestyle programmes provided through a mobile phone application have yet to be evaluated by RCTs in couples undergoing IVF. Study design, size, duration: A multicentre RCT (1:1) was carried out. The RCT started in January 2019 and was prematurely stopped because of the Covid-19 pandemic, leading to a reduced sample size (211 couples initiating IVF) and change in primary outcome (cumulative ongoing pregnancy to time to ongoing pregnancy). Participants/materials, setting, methods: Heterosexual couples initiating IVF in five fertility clinics were randomized between an attention control arm and an intervention arm for 12 months. The attention control arm received treatment information by mobile phone in addition to standard care. The intervention arm received the blended preconception lifestyle (PreLiFe)-programme in addition to standard care. The PreLiFe-programme included a mobile application, offering tailored advice and skills training on diet, physical activity and mindfulness, in combination with motivational interviewing over the telephone. The primary outcome was 'time to ongoing pregnancy'. Secondary reproductive outcomes included the Core Outcome Measures for Infertility Trials and IVF discontinuation. Changes in the following secondary lifestyle outcomes

Details

Database :
OAIster
Journal :
Human Reproduction vol.2023 (2023) nr.4 [ISSN 0268-1161]
Notes :
DOI: 10.1093/hropen/hoad036, Human Reproduction vol.2023 (2023) nr.4 [ISSN 0268-1161], English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1410386727
Document Type :
Electronic Resource