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1-(3,4-Dimethoxyphenyl)-3-(4-methoxyphenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1-one

Authors :
Universidad de Alicante. Departamento de Química Orgánica
Universidad de Alicante. Instituto Universitario de Síntesis Orgánica
Nacher-Luis, Anna
Pastor, Isidro M.
Universidad de Alicante. Departamento de Química Orgánica
Universidad de Alicante. Instituto Universitario de Síntesis Orgánica
Nacher-Luis, Anna
Pastor, Isidro M.
Publication Year :
2024

Abstract

The study of new catalytic protocols for the synthesis of organic compounds with a more sustainable perspective is of interest. The use of ionic organic solids, such as 1,3-bis(carboxymethyl)imidazolium chloride as a catalyst has allowed the Michael addition of N-heterocycles to chalcones. This methodology has been applied to the unique preparation of the potential bioactive compound 1-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1-one with moderate yield, due to the retro-Michael reaction. Both synthetic reactions (i.e., preparation of chalcone and triazole Michael-addition to chalcone) have good green metrics.

Details

Database :
OAIster
Publication Type :
Electronic Resource
Accession number :
edsoai.on1427413458
Document Type :
Electronic Resource