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DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O-Schiff base copper(II) complexes: Scientific paper

Authors :
Mijatović, Aleksandar
Cakovic, Angelina
Lolić, Aleksandar
Sretenovic, Snezana
Zivanovic, Marko
Petrović, Biljana
Bogojeski, Jovana
Seklic, Dragana
Mijatović, Aleksandar
Cakovic, Angelina
Lolić, Aleksandar
Sretenovic, Snezana
Zivanovic, Marko
Petrović, Biljana
Bogojeski, Jovana
Seklic, Dragana
Source :
Journal of the Serbian Chemical Society
Publication Year :
2023

Abstract

Three Schiff base Cu(II) complexes, (N,N’-bis(acetylacetone)­propyl­enediimine)copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis-(ben­zoyl­acet­one)propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and (N,N’-bis-(trifluoroacetylacetone)propylenediimine)­copper(II) complex, [Cu(tfacac2pn)] (3), were used to investigate the interactions with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) using the electronic absorption and spectro­scopic fluorescence methods. UV–Vis absorption studies showed that studied complexes interact with DNA molecule and exhibit moderate binding affinity. Fluorescence studies of complexes 1–3 also showed a possibility for DNA int­ercalation as well as a relatively high binding ability toward BSA. Among the tested complexes, the highest affinity for DNA and BSA molecules was shown by complex 1. Cytotoxic analyses, performed on human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell lines, showed that complex 2 exhibited activity on both cell lines, while complexes 1 and 3 did not show any activity.

Details

Database :
OAIster
Journal :
Journal of the Serbian Chemical Society
Notes :
Journal of the Serbian Chemical Society
Publication Type :
Electronic Resource
Accession number :
edsoai.on1427436017
Document Type :
Electronic Resource