Hearing loss and its association with the proteome of perilymph, cerebrospinal fluid, and tumor tissue in patients with vestibular schwannoma

Mass spectrometry analysis of the inner ear fluid, perilymph, cerebrospinal fluid, and vestibular schwannoma proteome and its relation to hearing loss in patients with vestibular schwannomas. Patients with severe to profound hearing loss, compared to those with normal hearing or mild hearing loss, exhibited an upregulation of Complement Factor H-related protein 2 (CFHR2) in the perilymph. This is indicative of increased inflammation in the inner ear, suggesting a potential cause of hearing loss in patients with vestibular schwannomas affecting the ear.