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Defining the Emergence of New Immunotherapy Approaches in Breast Cancer: Role of Myeloid-Derived Suppressor Cells

Authors :
Universidad de Sevilla. Departamento de Medicina
Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología
Sánchez León, María Luisa
Jiménez Cortegana, Carlos
Silva Romeiro, Silvia
Garnacho Montero, Carmen
Cruz Merino, Luis de la
García-Domínguez, Daniel J.
Hontecillas-Prieto, Lourdes
Sánchez Margalet, Víctor
Universidad de Sevilla. Departamento de Medicina
Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología
Sánchez León, María Luisa
Jiménez Cortegana, Carlos
Silva Romeiro, Silvia
Garnacho Montero, Carmen
Cruz Merino, Luis de la
García-Domínguez, Daniel J.
Hontecillas-Prieto, Lourdes
Sánchez Margalet, Víctor
Publication Year :
2023

Abstract

Breast cancer (BC) continues to be the most diagnosed tumor in women and a very heterogeneous disease both inter- and intratumoral, mainly given by the variety of molecular profiles with different biological and clinical characteristics. Despite the advancements in early detection and therapeutic strategies, the survival rate is low in patients who develop metastatic disease. Therefore, it is mandatory to explore new approaches to achieve better responses. In this regard, immunotherapy arose as a promising alternative to conventional treatments due to its ability to modulate the immune system, which may play a dual role in this disease since the relationship between the immune system and BC cells depends on several factors: the tumor histology and size, as well as the involvement of lymph nodes, immune cells, and molecules that are part of the tumor microenvironment. Particularly, myeloid-derived suppressor cell (MDSC) expansion is one of the major immunosuppressive mechanisms used by breast tumors since it has been associated with worse clinical stage, metastatic burden, and poor efficacy of immunotherapies. This review focuses on the new immunotherapies in BC in the last five years. Additionally, the role of MDSC as a therapeutic target in breast cancer will be described.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1428434728
Document Type :
Electronic Resource