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Cortical Amyloid Burden Relates to Basal Forebrain Volume in Subjective Cognitive Decline

Authors :
Daamen, Marcel
Scheef, Lukas
Li, Shumei
Grothe, Michel J.
Gaertner, Florian C.
Buchert, Ralph
Buerger, Katharina
Dobisch, Laura
Drzezga, Alexander
Essler, Markus
Ewers, Michael
Fliessbach, Klaus
Herrera Meléndez, Ana Lucía
Hetzer, Stefan
Janowitz, Daniel
Kilimann, Ingo
Krause, Bernd Joachim
Lange, Catharina
Laske, Christoph
Munk, Matthias H.
Peters, Oliver
Priller, Josef
Ramírez, Alfredo
Reimold, Matthias
Rominger, Axel
Rostamzadeh, Ayda
Roeske, Sandra
Roy, Nina
Scheffler, Klaus
Schneider, Anja
Spottke, Annika
Spruth, Eike Jakob
Teipel, Stefan J.
Wagner, Michael
Düzel, Emrah
Jessen, Frank
Boecker, Henning
DELCODE Study Group
Daamen, Marcel
Scheef, Lukas
Li, Shumei
Grothe, Michel J.
Gaertner, Florian C.
Buchert, Ralph
Buerger, Katharina
Dobisch, Laura
Drzezga, Alexander
Essler, Markus
Ewers, Michael
Fliessbach, Klaus
Herrera Meléndez, Ana Lucía
Hetzer, Stefan
Janowitz, Daniel
Kilimann, Ingo
Krause, Bernd Joachim
Lange, Catharina
Laske, Christoph
Munk, Matthias H.
Peters, Oliver
Priller, Josef
Ramírez, Alfredo
Reimold, Matthias
Rominger, Axel
Rostamzadeh, Ayda
Roeske, Sandra
Roy, Nina
Scheffler, Klaus
Schneider, Anja
Spottke, Annika
Spruth, Eike Jakob
Teipel, Stefan J.
Wagner, Michael
Düzel, Emrah
Jessen, Frank
Boecker, Henning
DELCODE Study Group
Publication Year :
2023

Abstract

Background: Atrophy of cholinergic basal forebrain (BF) nuclei is a frequent finding in magnetic resonance imaging (MRI) volumetry studies that examined patients with prodromal or clinical Alzheimer’s disease (AD), but less clear for individuals in earlier stages of the clinical AD continuum. Objective: To examine BF volume reductions in subjective cognitive decline (SCD) participants with AD pathologic changes. Methods: The present study compared MRI-based BF volume measurements in age- and sex-matched samples of N = 24 amyloid-positive and N = 24 amyloid-negative SCD individuals, based on binary visual ratings of Florbetaben positron emission tomography (PET) measurements. Additionally, we assessed associations of BF volume with cortical amyloid burden, based on semiquantitative Centiloid (CL) analyses. Results: Group differences approached significance for BF total volume (p = 0.061) and the Ch4 subregion (p = 0.059) only, showing the expected relative volume reductions for the amyloid-positive subgroup. There were also significant inverse correlations between BF volumes and CL values, which again were most robust for BF total volume and the Ch4 subregion. Conclusions: The results are consistent with the hypothesis that amyloid-positive SCD individuals, which are considered to represent a transitional stage on the clinical AD continuum, already show incipient alterations of BF integrity. The negative association with a continuous measure of cortical amyloid burden also suggests that this may reflect an incremental process. Yet, further research is needed to evaluate whether BF changes already emerge at “grey zone” levels of amyloid accumulation, before amyloidosis is reliably detected by PET visual readings.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1431964690
Document Type :
Electronic Resource