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Solubility-Permeability Interplay in Facilitating the Prediction of Drug Disposition Routes, Extent of Absorption, Food Effects, Brain Penetration and Drug Induced Liver Injury Potential
- Source :
- Journal of Pharmaceutical Sciences; vol 112, iss 9, 2326-2331; 1520-6017
- Publication Year :
- 2023
-
Abstract
- Here I detail the use of measures of permeability rate and solubility in predicting drug disposition characteristics through the utilization of the Biopharmaceutics Drug Disposition Classification System (BDDCS) and the Extended Clearance Classification System (ECCS) as well as the accuracy of the systems in predicting the major route of elimination and the extent of oral absorption of a new small molecule therapeutics. I compare the BDDCS and ECCS with the FDA Biopharmaceutics Classification System (BCS). I also detail the use of the BCS in predicting food effects and the BDDCS in predicting brain disposition of small molecule therapeutics and in validating DILI predictive metrics. This review provides an update of the current status of these classification systems and their uses in the drug development process.
Details
- Database :
- OAIster
- Journal :
- Journal of Pharmaceutical Sciences; vol 112, iss 9, 2326-2331; 1520-6017
- Notes :
- application/pdf, Journal of Pharmaceutical Sciences vol 112, iss 9, 2326-2331 1520-6017
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1432079815
- Document Type :
- Electronic Resource