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Cardiovascular diseases after high-dose chemotherapy and autologous stem cell transplant for lymphoma:A Danish population-based study
- Source :
- Baech , J , Husby , S , Trab , T , Kragholm , K , Brown , P , Gørløv , J S , Jørgensen , J M , Gudbrandsdottir , S , Severinsen , M T , Grønbæk , K , Larsen , T S , Wästerlid , T , Eloranta , S , Smeland , K B , Jakobsen , L H & El-Galaly , T C 2024 , ' Cardiovascular diseases after high-dose chemotherapy and autologous stem cell transplant for lymphoma : A Danish population-based study ' , British Journal of Haematology , vol. 204 , no. 3 , pp. 967-975 .
- Publication Year :
- 2024
-
Abstract
- Cardiovascular diseases, especially congestive heart failure (CHF), are known complications of anthracyclines, but the risk for patients undergoing high-dose chemotherapy and autologous stem cell transplant (HDT-ASCT) is not well established. With T-cell therapies emerging as alternatives, studies of long-term complications after HDT-ASCT are warranted. Danish patients treated with HDT-ASCT for aggressive lymphoma between 2001 and 2017 were matched 1:5 on sex, birth year and Charlson comorbidity score to the general population. Events were captured using nationwide registers. A total of 787 patients treated with HDT-ASCT were identified. Median follow-up was 7.6 years. The risk of CHF was significantly increased in the HDT-ASCT population compared to matched comparators with an adjusted hazard ratio (HR) of 5.5 (3.8–8.1). The 10-year cumulative incidence of CHF was 8.0% versus 2.0% (p < 0.001). Male sex, ≥2 lines of therapy, hypertension and cumulative anthracycline dose (≥300 mg/m2) were risk factors for CHF. In a separate cohort of 4089 lymphoma patients, HDT-ASCT was also significantly associated with increased risk of CHF (adjusted HR of 2.6 [1.8–3.8]) when analysed as a time-dependent exposure. HDT-ASCT also increased the risk of other cardiac diseases. These findings are applicable for the benefit/risk assessment of HDT-ASCT versus novel therapies.
Details
- Database :
- OAIster
- Journal :
- Baech , J , Husby , S , Trab , T , Kragholm , K , Brown , P , Gørløv , J S , Jørgensen , J M , Gudbrandsdottir , S , Severinsen , M T , Grønbæk , K , Larsen , T S , Wästerlid , T , Eloranta , S , Smeland , K B , Jakobsen , L H & El-Galaly , T C 2024 , ' Cardiovascular diseases after high-dose chemotherapy and autologous stem cell transplant for lymphoma : A Danish population-based study ' , British Journal of Haematology , vol. 204 , no. 3 , pp. 967-975 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1439095219
- Document Type :
- Electronic Resource