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Atomic force microscopy-coupled microcoils for cellular-scale nuclear magnetic resonance spectroscopy

Authors :
Mousoulis, Charilaos
Maleki, Teimour
Ziaie, Babak
Neu, Corey
Mousoulis, Charilaos
Maleki, Teimour
Ziaie, Babak
Neu, Corey
Source :
Birck and NCN Publications
Publication Year :
2013

Abstract

We present the coupling of atomic force microscopy (AFM) and nuclear magnetic resonance (NMR) technologies to enable topographical, mechanical, and chemical profiling of biological samples. Here, we fabricate and perform proof-of-concept testing of radiofrequency planar microcoils on commercial AFM cantilevers. The sensitive region of the coil was estimated to cover an approximate volume of 19.4 x 10(3) mu m(3) (19.4 pl). Functionality of the spectroscopic module of the prototype device is illustrated through the detection of H-1 resonance in deionized water. The acquired spectra depict combined NMR capability with AFM that may ultimately enable biophysical and biochemical studies at the single cell level. (C) 2013 AIP Publishing LLC

Details

Database :
OAIster
Journal :
Birck and NCN Publications
Notes :
application/pdf
Publication Type :
Electronic Resource
Accession number :
edsoai.on1455863620
Document Type :
Electronic Resource