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Pulmonary function and atherosclerosis in the general population : causal associations and clinical implications

Pulmonary function and atherosclerosis in the general population : causal associations and clinical implications

Authors :
Engström, G.
Lampa, Erik
Dekkers, Koen
Lin, Yi-Ting
Ahlm, K.
Ahlström, Håkan
Alfredsson, J.
Bergström, G.
Blomberg, A.
Brandberg, J.
Caidahl, K.
Cederlund, K.
Duvernoy, Olov
Engvall, J. E.
Eriksson, M. J.
Fall, Tove
Gigante, B.
Gummesson, A.
Hagström, Emil
Hamrefors, V.
Hedner, J.
Janzon, M.
Jernberg, T.
Johnson, L.
Lind, Lars
Lindberg, Eva
Mannila, M.
Nilsson, U.
Persson, A.
Persson, H. L.
Persson, M.
Ramnemark, A.
Rosengren, A.
Schmidt, C.
Skoglund Larsson, L.
Sköld, C. M.
Swahn, E.
Söderberg, S.
Torén, K.
Waldenström, A.
Wollmer, P.
Zaigham, Suneela
Östgren, C. J.
Sundström, Johan
Engström, G.
Lampa, Erik
Dekkers, Koen
Lin, Yi-Ting
Ahlm, K.
Ahlström, Håkan
Alfredsson, J.
Bergström, G.
Blomberg, A.
Brandberg, J.
Caidahl, K.
Cederlund, K.
Duvernoy, Olov
Engvall, J. E.
Eriksson, M. J.
Fall, Tove
Gigante, B.
Gummesson, A.
Hagström, Emil
Hamrefors, V.
Hedner, J.
Janzon, M.
Jernberg, T.
Johnson, L.
Lind, Lars
Lindberg, Eva
Mannila, M.
Nilsson, U.
Persson, A.
Persson, H. L.
Persson, M.
Ramnemark, A.
Rosengren, A.
Schmidt, C.
Skoglund Larsson, L.
Sköld, C. M.
Swahn, E.
Söderberg, S.
Torén, K.
Waldenström, A.
Wollmer, P.
Zaigham, Suneela
Östgren, C. J.
Sundström, Johan
Publication Year :
2024

Abstract

Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50-64 years. The results were confirmed using 2-sample Mendelian randomization. Lower lung function and emphysema were associated with more atherosclerosis, but these relationships were attenuated after adjustment for cardiovascular risk factors. Lung function was not associated with coronary atherosclerosis in 14,524 never-smokers. No potentially causal effect of lung function on atherosclerosis, or vice versa, was found in the 2-sample Mendelian randomization analysis. Here we show that reduced lung function and atherosclerosis are correlated in the population, but probably not causally related. Assessing lung function in addition to conventional cardiovascular risk factors to gauge risk of subclinical atherosclerosis is probably not meaningful, but low lung function found by chance should alert for atherosclerosis.

Details

Database :
OAIster
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1457293203
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1007.s10654-023-01088-z