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Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

Authors :
50632098
10759509
Tamura, Tomokazu
Ito, Jumpei
Uriu, Keiya
Zahradnik, Jiri
Kida, Izumi
Anraku, Yuki
Nasser, Hesham
Shofa, Maya
Oda, Yoshitaka
Lytras, Spyros
Nao, Naganori
Itakura, Yukari
Deguchi, Sayaka
Suzuki, Rigel
Wang, Lei
Begum, MST Monira
Kita, Shunsuke
Yajima, Hisano
Sasaki, Jiei
Sasaki-Tabata, Kaori
Shimizu, Ryo
Tsuda, Masumi
Kosugi, Yusuke
Fujita, Shigeru
Pan, Lin
Sauter, Daniel
Yoshimatsu, Kumiko
Suzuki, Saori
Asakura, Hiroyuki
Nagashima, Mami
Sadamasu, Kenji
Yoshimura, Kazuhisa
Yamamoto, Yuki
Nagamoto, Tetsuharu
Schreiber, Gideon
Maenaka, Katsumi
The Genotype to Phenotype Japan (G2P-Japan)
Hashiguchi, Takao
Ikeda, Terumasa
Fukuhara, Takasuke
Saito, Akatsuki
Tanaka, Shinya
Matsuno, Keita
Takayama, Kazuo
Sato, Kei
50632098
10759509
Tamura, Tomokazu
Ito, Jumpei
Uriu, Keiya
Zahradnik, Jiri
Kida, Izumi
Anraku, Yuki
Nasser, Hesham
Shofa, Maya
Oda, Yoshitaka
Lytras, Spyros
Nao, Naganori
Itakura, Yukari
Deguchi, Sayaka
Suzuki, Rigel
Wang, Lei
Begum, MST Monira
Kita, Shunsuke
Yajima, Hisano
Sasaki, Jiei
Sasaki-Tabata, Kaori
Shimizu, Ryo
Tsuda, Masumi
Kosugi, Yusuke
Fujita, Shigeru
Pan, Lin
Sauter, Daniel
Yoshimatsu, Kumiko
Suzuki, Saori
Asakura, Hiroyuki
Nagashima, Mami
Sadamasu, Kenji
Yoshimura, Kazuhisa
Yamamoto, Yuki
Nagamoto, Tetsuharu
Schreiber, Gideon
Maenaka, Katsumi
The Genotype to Phenotype Japan (G2P-Japan)
Hashiguchi, Takao
Ikeda, Terumasa
Fukuhara, Takasuke
Saito, Akatsuki
Tanaka, Shinya
Matsuno, Keita
Takayama, Kazuo
Sato, Kei
Publication Year :
2023

Abstract

In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during the summer of 2022. XBB.1 is the variant most profoundly resistant to BA.2/5 breakthrough infection sera to date and is more fusogenic than BA.2.75. The recombination breakpoint is located in the receptor-binding domain of spike, and each region of the recombinant spike confers immune evasion and increases fusogenicity. We further provide the structural basis for the interaction between XBB.1 spike and human ACE2. Finally, the intrinsic pathogenicity of XBB.1 in male hamsters is comparable to or even lower than that of BA.2.75. Our multiscale investigation provides evidence suggesting that XBB is the first observed SARS-CoV-2 variant to increase its fitness through recombination rather than substitutions.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1458646743
Document Type :
Electronic Resource