Decreased Thalamic Activity Is a Correlate for Disconnectedness during Anesthesia with Propofol, Dexmedetomidine and Sevoflurane But Not S-Ketamine

CC BY 4.0Correspondence should be addressed to Harry Scheinin at harry.scheinin@utu.fiThis work was supported by Academy of Finland, Helsinki, Finland Grant Numbers 266467 and 266434; Jane and Aatos Erkko Foundation, Helsinki, Finland; VSSHP-EVO Grant Numbers 13323 and L3824, Turku, Finland; Doctoral Programme of Clinical Investigation, University of Turku Graduate School, Turku, Finland (O.K., A.S., L.R.); Paulo Foundation, Espoo, Finland (A.S.); Finnish Medical Foundation, Helsinki, Finland (O.K., A.S.); The Orion Research Foundation, Espoo, Finland (A.S.); Signe and Ane Gyllenberg Foundation (O.K.); and Emil Aaltonen Foundation (O.K.,L.L., R.E.K.). We thank the radiographers and anesthesia nurses at Turku PET Centre for excellent technical assistance and Ms. Saija Sirén, Lic. Phil., for the analysis of drug concentrations in plasma.