Immunohistochemical characteristics of structural changes in the cortex and medulla of the adrenal glands under the influence of a food additive complex

The data obtained during the experiment allow us to conclude that the influence of the complex of food addi tives sodium glutamate, sodium nitrite and Ponceau 4R is a mechanism of activation of the focus of inflammation and changes in the structural elements of the adrenal glands and hemomicrocirculatory bed. According to the data of an immunohistochemical study, it was established that in the cortex and medulla of the adrenal glands, Ki-67 positive cells are elements of the local protective barrier. The largest number of Ki 67-positive cells was determined in the walls of fenes trated capillaries that permeate the cortex and medulla of the adrenal glands. Ki-67-positive cells formed clusters of 2-10 cells at the border of the glomerular and reticular zones. The total number of Ki-67-positive cells varied ac cording to the week of the experimental study. Starting from the first week, the number of cells expressing Ki-67 increases dramatically in the adrenal cortex’s glomerular, fasciculate and reticular zones. In the fourth week of the experiment, the level of labeled cells with Ki-67 reached almost control values. However, at the 12th week, the number of cells expressing Ki-67 increases in the cortex and the medulla. On the 16th week, the indicators remain within the 12th week, with an increase in the number of Ki-67-positive cells in the fasciculate zone of the cortical substance of the adrenal glands.