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Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Authors :
Toporcov, Tatiana Natasha Znaor, Ariana Zhang, Zuo-Feng Yu, Guo-Pei Winn, Deborah M. Wei, Qingyi Vilensky, Marta and Vaughan, Thomas Thomson, Peter Talamini, Renato and Szeszenia-Dabrowska, Neonila Sturgis, Erich M. Smith, Elaine and Shangina, Oxana Schwartz, Stephen M. Schantz, Stimson and Rudnai, Peter Richiardi, Lorenzo Ramroth, Heribert Purdue, Mark P. Olshan, Andrew F. Eluf-Neto, Jose Muscat, Joshua and Moyses, Raquel Ajub Morgenstern, Hal Menezes, Ana McClean, Michael Matsuo, Keitaro Mates, Dana Macfarlane, Tatiana V. and Lissowska, Jolanta Levi, Fabio Lazarus, Philip La Vecchia, Carlo Lagiou, Pagona Koifman, Sergio Kjaerheim, Kristina Kelsey, Karl Holcatova, Ivana Herrero, Rolando and Healy, Claire Hayes, Richard B. Franceschi, Silvia and Fernandez, Leticia Fabianova, Eleonora Daudt, Alexander W. and Curioni, Otavio Alberto Dal Maso, Luigino Curado, Maria Paula and Conway, David I. Chen, Chu Castellsague, Xavier Canova, Cristina Cadoni, Gabriella Brennan, Paul Boccia, Stefania and Antunes, Jose Leopoldo Ferreira Ahrens, Wolfgang Agudo, Antonio Boffetta, Paolo Hashibe, Mia Lee, Yuan-Chin Amy and Wuensch Filho, Victor
Toporcov, Tatiana Natasha Znaor, Ariana Zhang, Zuo-Feng Yu, Guo-Pei Winn, Deborah M. Wei, Qingyi Vilensky, Marta and Vaughan, Thomas Thomson, Peter Talamini, Renato and Szeszenia-Dabrowska, Neonila Sturgis, Erich M. Smith, Elaine and Shangina, Oxana Schwartz, Stephen M. Schantz, Stimson and Rudnai, Peter Richiardi, Lorenzo Ramroth, Heribert Purdue, Mark P. Olshan, Andrew F. Eluf-Neto, Jose Muscat, Joshua and Moyses, Raquel Ajub Morgenstern, Hal Menezes, Ana McClean, Michael Matsuo, Keitaro Mates, Dana Macfarlane, Tatiana V. and Lissowska, Jolanta Levi, Fabio Lazarus, Philip La Vecchia, Carlo Lagiou, Pagona Koifman, Sergio Kjaerheim, Kristina Kelsey, Karl Holcatova, Ivana Herrero, Rolando and Healy, Claire Hayes, Richard B. Franceschi, Silvia and Fernandez, Leticia Fabianova, Eleonora Daudt, Alexander W. and Curioni, Otavio Alberto Dal Maso, Luigino Curado, Maria Paula and Conway, David I. Chen, Chu Castellsague, Xavier Canova, Cristina Cadoni, Gabriella Brennan, Paul Boccia, Stefania and Antunes, Jose Leopoldo Ferreira Ahrens, Wolfgang Agudo, Antonio Boffetta, Paolo Hashibe, Mia Lee, Yuan-Chin Amy and Wuensch Filho, Victor
Publication Year :
2015

Abstract

Background: Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients. Methods: We pooled data from 25 case-control studies and conducted separate analyses for adults <= 45 years old (’young adults’, 2010 cases and 4042 controls) and > 45 years old (’older adults’, 17 700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results: The young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, =19.9% (95% CI = 9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking = 5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR = 2.27 (95% CI = 1.26, 4.10)], but not in the older adults [OR = 1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2 .41%, 5.80%) in older adults. Conclusions: Differences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1478827050
Document Type :
Electronic Resource

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