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Induction of [?eta]-Adrenergic Metaplasticity of LTP Requires Intact Anchoring of PKA
- Source :
-
Learning & Memory . Jun 2019 26(6):187-190. - Publication Year :
- 2019
-
Abstract
- Beta-adrenergic receptors ([beta]-ARs) prime hippocampal synapses to stabilize long-term potentiation (LTP). This "metaplasticity" can persist for 1-2 h after pharmacologic activation of [beta]-ARs. It requires activation of PKA (cAMP-dependent protein kinase) during [beta]-AR priming. A-kinase anchoring proteins (AKAPs) tether PKA to downstream signaling proteins. We hypothesized that induction of this metaplasticity requires intact functioning of AKAPs. Acute application of stearated ht31, a membrane-permeant inhibitor of AKAPs, either during [beta]-AR activation 30 min prior to LTP induction or during LTP induction, attenuated the persistence of LTP. A control, inactive ht31 peptide did not affect [beta]-AR-mediated metaplasticity. These findings implicate PKA anchoring in the induction of [beta]-adrenergic metaplasticity of LTP.
Details
- Language :
- English
- ISSN :
- 1072-0502
- Volume :
- 26
- Issue :
- 6
- Database :
- ERIC
- Journal :
- Learning & Memory
- Publication Type :
- Academic Journal
- Accession number :
- EJ1219120
- Document Type :
- Journal Articles<br />Reports - Research
- Full Text :
- https://doi.org/10.1101/lm.049635.119