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Reminders Reinstate Context-Specificity to Generalized Remote Memories in Rats: Relation to Activity in the Hippocampus and aCC
- Source :
-
Learning & Memory . Jan 2020 27(1):1-5. - Publication Year :
- 2020
-
Abstract
- Conditioned fear memories that are context-specific shortly after conditioning generalize over time. We exposed rats to a context reminder 30 d after conditioning, which served to reinstate context-specificity, and investigated how this reminder alters retrieval-induced activity in the hippocampus and anterior cingulate cortex (aCC) relative to a no reminder condition. c-Fos expression in dorsal CA1 was observed following retrieval in the original context, but not in a novel context, whether or not the memory was reactivated, suggesting that dCA1 retains the context-specific representation. c-Fos was highly expressed in aCC following remote memory testing in both contexts, regardless of reminder condition, indicating that aCC develops generalized representations that are insensitive to memory reactivation.
Details
- Language :
- English
- ISSN :
- 1072-0502
- Volume :
- 27
- Issue :
- 1
- Database :
- ERIC
- Journal :
- Learning & Memory
- Publication Type :
- Academic Journal
- Accession number :
- EJ1241468
- Document Type :
- Journal Articles<br />Reports - Descriptive
- Full Text :
- https://doi.org/10.1101/lm.050161.119