Back to Search
Start Over
Autism Spectrum Phenotype in Males and Females with Fragile X Full Mutation and Premutation
- Source :
-
Journal of Autism and Developmental Disorders . Apr 2007 37(4):738-747. - Publication Year :
- 2007
-
Abstract
- The behavioural phenotype of autism was assessed in individuals with full mutation and premutation fragile X syndrome (FXS) using the Autism Diagnostic Observation Scale-Generic (ADOS-G) and the Autism Diagnostic Interview (ADI-R). The participants, aged 5-80 years, comprised 33 males and 31 females with full mutation, 7 males and 43 females with premutation, and 38 non-fragile X relatives (29 males, 9 females). In the full mutation group, a total of 67% males and 23% females met either the Autism Disorder (AD) or the Autism Spectrum Disorder (ASD) criteria on at least one of the diagnostic tests. In the premutation group, 14% males and 5% females met the ADOS-G criteria for ASD. The presence of autism manifestations in males and females with full mutation and premutation provide support for a spectrum view.
Details
- Language :
- English
- ISSN :
- 0162-3257
- Volume :
- 37
- Issue :
- 4
- Database :
- ERIC
- Journal :
- Journal of Autism and Developmental Disorders
- Publication Type :
- Academic Journal
- Accession number :
- EJ760890
- Document Type :
- Journal Articles<br />Reports - Evaluative
- Full Text :
- https://doi.org/10.1007/s10803-006-0205-z